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EC number: 945-065-4 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Bioaccumulation : aquatic/sediment:
Using Bio-concentration Factor (v12.1.0.50374) module Bio-concentration Factor at range pH 1-14 of the chemical N-(2-ethylhexyl)-1-[[2-methyl-4-[ (4-methylphenyl) azo]phenyl]azo]naphthalen-2-amine(CAS no.93964 -07 -9) estimated to be> 1000000.0dimensionless. This value indicates that the chemical N-(2-ethylhexyl)-1-[[2-methyl-4-[ (4-methylphenyl) azo]phenyl]azo]naphthalen-2-amine is very bioaccumulative in aquatic organisms as this value exceeded 2000 criteria.
Additional information
Bioaccumulation : aquatic/sediment:
Various predicted data for the target compound N-(2-ethylhexyl)-1-[[2-methyl-4-[(4-methylphenyl)azo]phenyl]azo]naphthalen-2-amine (CAS No. 93964-07-9) and supporting weight of evidence studies for its read across substance were reviewed for the bioaccumulation end point and their results are summarized as below:
Bioaccumulation potential of the test material was estimated using ACD (Advanced Chemistry Development)/I-Lab; Algorithm Version: v5.0.0.184
Using Bio-concentration Factor (v12.1.0.50374) module Bio-concentration Factor at range pH 1-14 of the chemical N-(2-ethylhexyl)-1-[[2-methyl-4-[ (4-methylphenyl) azo]phenyl]azo]naphthalen-2-amine (CAS no.93964 -07 -9) estimated to be > 1000000.0 dimensionless. This value indicates that the chemical N-(2-ethylhexyl)-1-[[2-methyl-4-[ (4-methylphenyl) azo]phenyl]azo]naphthalen-2-amine is very bioaccumulative in aquatic organisms as this value exceeded 2000 criteria.
The above prediction was further supported by another predicted data estimated by SciFinder, American Chemical Society (ACS); 2017
The Bioconcentration factor (BCF) for test chemical N-(2-ethylhexyl)-1-[[2-methyl-4-[(4-methylphenyl)azo]phenyl]azo]naphthalen-2-amine (CAS No: 93964-07-9) was predicted in aquatic organisms by Scifinder database at pH 1-10 and temperature 25 °C .The Bioconcentration factor (BCF) of test substance N-(2-ethylhexyl)-1-[[2-methyl-4-[(4-methylphenyl)azo]phenyl]azo]naphthalen-2-amine at pH 1-10 and temperature 25 °C was estimated to be 1.00E6 dimensionless. This BCF value at pH 1-10 and temperature 25 °C suggests that the test chemical N-(2-ethylhexyl)-1-[[2-methyl-4-[(4-methylphenyl)azo]phenyl]azo]naphthalen-2-amine is very bioaccumulative in aquatic organisms.
Another predicted data was estimated using ChemSpider- Free chemical Database, Royal Society of Chemistry, 2017) was used for predicting the bioconcentration factor (BCF) of test chemical N-(2-ethylhexyl)-1-[[2-methyl-4-[(4-methylphenyl)azo]phenyl]azo]naphthalen-2-amine.
The Bioconcentration factor (BCF) for test chemical N-(2-ethylhexyl)-1-[[2-methyl-4-[(4-methylphenyl)azo]phenyl]azo]naphthalen-2-amine (CAS No: 93964-07-8) was predicted in aquatic organisms by Chemspider- ACD/PhysChem Suite at pH 5.5 and pH 7.4.The Bioconcentration factor (BCF) of test substance N-(2-ethylhexyl)-1-[[2-methyl-4-[(4-methylphenyl)azo]phenyl]azo]naphthalen-2-amine at pH 5.5 and pH 7.4 was estimated to be 1000000.00 dimensionless. This BCF value suggests that the test chemical N-(2-ethylhexyl)-1-[[2-methyl-4-[(4-methylphenyl)azo]phenyl]azo]naphthalen-2-amine is very bioaccumulative in aquatic organisms.
The above prediction was further supported by experimental data summarized in HSDB (Hazardous Substances Data Bank); US national Library of Medicine reviewed by SRC, 2017 in this study the BCF of test chemical in aquatic organisms was reported as 290000 using a measured log Kow of 7.5 and a recommended regression-derived equation. This BCF value indicates that bioconcentration in aquatic organisms will be an important fate process.
On the basis of above results for target chemical N-(2-ethylhexyl)-1-[[2-methyl-4-[(4-methylphenyl)azo]phenyl]azo]naphthalen-2-amine(from ACD labs, ChemSpider, SciFinder database and CompTox Chemistry Dashboard, 2017) and for its read across substance (from authoritative database HSDB), it can be concluded that the BCF value of test substance N-(2-ethylhexyl)-1-[[2-methyl-4-[(4-methylphenyl)azo]phenyl]azo]naphthalen-2-amine ranges from 1000000.00 - 290000 which exceeds the bioconcentration threshold of 2000, indicating that the chemical N-(2-ethylhexyl)-1-[[2-methyl-4-[(4-methylphenyl)azo]phenyl]azo]naphthalen-2-amine is expected to be very bioaccumulate in the food chain.
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