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EC number: 200-782-5 | CAS number: 72-48-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30/01/2017 to 04/04/2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
Test material
- Reference substance name:
- 1,2-dihydroxyanthraquinone
- EC Number:
- 200-782-5
- EC Name:
- 1,2-dihydroxyanthraquinone
- Cas Number:
- 72-48-0
- Molecular formula:
- C14H8O4
- IUPAC Name:
- 1,2-dihydroxy-9,10-dihydroanthracene-9,10-dione
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Appearance: solid yellow powder
Constituent 1
Results and discussion
Water solubility
- Key result
- Water solubility:
- 0.483 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 4.5
Any other information on results incl. tables
Preliminary test result:
Test Item |
total volume of ultra-pure water |
time of shaking |
remarks |
Approximate solubility |
|
100 |
10 |
not completely dissolved |
< 101 |
10.1 |
200 |
10 |
not completely dissolved |
< 50.5 |
|
300 |
10 |
not completely dissolved |
< 33.7 |
|
400 |
10 |
not completely dissolved |
< 25.3 |
|
500 |
10 |
not completely dissolved |
< 20.2 |
|
1000 |
10 |
not completely dissolved |
< 10.1 |
|
1000 |
17 hours |
not completely dissolved |
< 10.1 |
|
1100 |
74 hours |
not completely dissolved |
< 9.2 |
The minimum amount of test item needed for the main test is: 5 x 9.2 mg/L = 46 mg/L = 2.3 mg/50 mL
Main test:
Amount of test item in each column: ≥ 2.5 mg at 50 mLwater
sampling time |
Analyte concentration column 1 (25 mL/h) |
Analyte concentration column 2 (8 mL/h) |
pH value |
pH value |
[h] |
[mg/L] |
[mg/L] |
|
|
405 |
0.512 |
0.598 |
4.5 |
4.5 |
429 |
0.338 |
0.373 |
4.5 |
4.5 |
453 |
0.461 |
0.513 |
4.5 |
4.5 |
479 |
0.424 |
0.577 |
4.5 |
4.5 |
501 |
0.478 |
0.551 |
4.5 |
4.5 |
Mean:* |
0.443 |
0.522 |
4.5 |
4.5 |
SD:* |
0.067 |
0.089 |
0.0 |
0.0 |
RSD [%]:* |
15.1 |
17.0 |
0.0 |
0.0 |
|
Analyte concentration [mg/L] |
pH Value |
Overall mean:* |
0.483 |
4.5 |
Overall AD:* |
0.079 |
0.0 |
Overall RD [%]:* |
16.4 |
0.0 |
SD: standard deviation; RSD: relative standard deviation; AD: absolute deviation; RD: relative deviation
* : values were calculated from the last 5 consecutive samples
The results indicate the required reproducibility (relative standard deviation below 30 %) and no tendency to increasing values, when the test time is prolonged.
The mean values obtained from the two tests with different flows did not differ by more than 30 %.
The analytical method used was validated. The calibration curve was linear with R= 1. The LOQ was set at 0.2318 mg/L and LOD at 0.1 mg/L. The recovery was found to be 98.6 % and 99.9 % for 0.2318 and 1.714 mg/L respectively.
Applicant's summary and conclusion
- Conclusions:
- The water solubility was determined to be 0.483 mg/L (20°C, pH 4.5).
- Executive summary:
In the current study the water solubility of the test item was determinde according to OECD guideline 105 (1995) and Council Regulation (EC) No. 440/2008 Method A.6. The study was according to GLP. The solubility of the test item was determined using the column elution method at 20 +/- 0.5°C.
The HPLC method (HPLC with UV detection ) for the determination of the content of Mordant Red 11 in aquaeous solutions was validated and tested with satisfactory results in regard to linearity of the detector, accuracy, precision and non-analyte interference of the analytical system.
The water solubility was determined to be 0.483 mg/L (20°C, pH 4.5).
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