Reaction mass of Benzenamine, N,N-dimethyl- , molybdate, tungstate & phosphates

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from peer reviewed journal.

Data source

Reference

Reference Type:

other: study report

Title:

Fragrance material review on α-methylbenzyl alcohol

Author:

J. Scognamiglio, L. Jones , C.S. Letizia, A.M. Api

Year:

2012

Bibliographic source:

Food and Chemical Toxicology 50 (2012) S124–S129

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: As mentioned below

Principles of method if other than guideline:

Acute dermal toxicity study was conducted on rabbits to evaluate the dermal toxic nature of the test compound.

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

1-phenylethanol

EC Number:

202-707-1

EC Name:

1-phenylethanol

Cas Number:

98-85-1

Molecular formula:

C8H10O

IUPAC Name:

1-phenylethanol

Test material form:

other: Liquid

Details on test material:

CAs No: 98-85-1
Chemical Name: α-methylbenzyl alcohol
Nature of chemical: Organic

Test animals

Species:

rabbit

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

not specified

Administration / exposure

Type of coverage:

other: Dermal

Vehicle:

not specified

Details on dermal exposure:

not specified

Duration of exposure:

24 hrs

Doses:

1250, 2500 or 5000 mg/Kg

No. of animals per sex per dose:

Total: 141250 mg/Kg: 62500 mg/Kg: 45000 mg/Kg: 4

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 24 hrs- Other examinations performed: Clinical signs, mortality

Statistics:

not specified

Results and discussion

Preliminary study:

not specified

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 2 500 mg/kg bw

Based on:

test mat.

Remarks on result:

other: No mortality was observed

Mortality:

All 4 animals dosed at 5000 mg/kg died within 24 h. There was no mortality at the two lower doses.

Clinical signs:

There were no clinical signs observed at any dose other than erythema and edema at the application site.

Body weight:

not specified

Gross pathology:

not specified

Other findings:

not specified

Applicant's summary and conclusion

Interpretation of results:

other: Not classified

Conclusions:

The acute dermal toxicity dose (LD50) of test chemical when administered to rabbits was considered to be >2500 mg/kg body weight. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that test chemical does not exhibits acute toxicity by the dermal route.

Executive summary:

Acute dermal toxicity study was conducted on rabbits to evaluate the dermal toxic nature of the test compound. The rabbits were given the doses of 1250 (n = 6), 2500 (n = 4) and 5000 (n = 4) mg/kg. There was no mortality at the two lower doses. There were no clinical signs observed at any dose other than erythema and edema at the application site.

It was concluded that the acute dermal median lethal dose (LD50) of test chemical when administered to rabbits was considered to be >2500 mg/kg body weight. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that  test chemical does not exhibits acute toxicity by the dermal route.