Registration Dossier
Registration Dossier
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EC number: 241-165-0 | CAS number: 17096-07-0
Endpoint summary
Administrative data
Description of key information
In the key acute oral toxicity study, conducted to the now deleted OECD TG 401 and in compliance with GLP, the reported LD50 value was greater than 10.0 mL/kg bw (equivalent to 9250 mg/kg bw) (CIVO, 1988).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 9 250 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In the key acute oral toxicity study, conducted to the now deleted OECD TG 401 and in compliance with GLP, the reported LD50 value was greater than 10.0 mL/kg bw (equivalent to 9250 mg/kg bw) (CIVO, 1988).
10.0 mL/kg bw of undiluted test material was administered orally to 5 male and 5 female rats. The rats were observed frequently for signs of intoxication, during the first 4 hours after treatment and thereafter, at least once daily for 14 days. The individual body weights of the rats were recorded on days 0, 3, 7, and 14. The animals were subject to necropsy at the end of the observation period.
The findings of the key study are supported by a study on the structural analogous substance, (1,1,3,3 -Tetramethyldisiloxane-1,3-diyl)dipropane-1,3-diyl dimethacrylate (CAS No. 18547-93-8), which reported an LD50 value greater than 2000 mg/kg bw (Eurofins, 2017). The study was conducted according to an appropriate OECD guideline and in compliance with GLP.
Justification for classification or non-classification
Based on the available data for 3-[tris(trimethylsiloxy)silyl]propylmethacrylate, no classification is required for acute toxicity according to Regulation (EC) No. 1272/2008.
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