Registration Dossier
Registration Dossier
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EC number: 288-678-6 | CAS number: 85865-79-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jan 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1986
- GLP compliance:
- no
Test material
- Reference substance name:
- Chromate(2-), [2-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]benzoato(2-)][2-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]-5-sulfobenzoato(3-)]-, lithium sodium
- EC Number:
- 288-678-6
- EC Name:
- Chromate(2-), [2-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]benzoato(2-)][2-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]-5-sulfobenzoato(3-)]-, lithium sodium
- Cas Number:
- 85865-79-8
- Molecular formula:
- C34H23CrLiN8NaO9S
- IUPAC Name:
- Chromate(2-), [2-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]benzoato(2-)][2-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]-5-sulfobenzoato(3-)]-, lithium sodium
- Test material form:
- solid: particulate/powder
- Details on test material:
- Acid Yellow 232
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- HC:NZW
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Interfauna UK ltd.
- Housing: individual, Cage type III-high
- Weight at study initiation: 3.0 - 3.4 kg
- Diet (e.g. ad libitum): "ssniff K4" ad libitum
- Water (e.g. ad libitum): tap water ad libitum
- Acclimation period: at least 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 +/- 2°C
- Humidity (%): 45 - 65%
- Photoperiod (hrs dark / hrs light): 12h/12h
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Remarks:
- to form a paste
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 500 mg test material mixed with water to have a thicker paste - Duration of treatment / exposure:
- 4 h exposure
- Observation period:
- 14 days
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 6 x 6cm
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with Water
- Time after start of exposure: 4h
OBSERVATION TIME POINTS
(indicate if minutes, hours or days) 1, 24, 48 and 72h and 7 and 14 days
SCORING SYSTEM:
Draize-Grade
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
Any other information on results incl. tables
| Animal No | Endpoint | Observation time | ||
| 24h | 48h | 72h | ||
| I | erythema | 0 | 0 | 0 |
| edema | 0 | 0 | 0 | |
| II | erythema | 0 | 0 | 0 |
| edema | 0 | 0 | 0 | |
| III | erythema | 0 | 0 | 0 |
| edema | 0 | 0 | 0 | |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No signs of irritation related to the substance were observed.
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