Registration Dossier
Registration Dossier
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EC number: 220-378-2 | CAS number: 2744-49-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Fluorescent Brightener 121
- IUPAC Name:
- Fluorescent Brightener 121
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.1 ml/eye
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: not available
- Time point:
- 24/48/72 h
- Remarks on result:
- other: not irritating
- Irritation parameter:
- iris score
- Basis:
- animal: not available
- Time point:
- 24/48/72 h
- Remarks on result:
- other: not irritating
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: not available
- Time point:
- 24/48/72 h
- Remarks on result:
- other: not irritating
- Irritation parameter:
- chemosis score
- Basis:
- animal: not available
- Time point:
- 24/48/72 h
- Remarks on result:
- other: not irritating
- Irritant / corrosive response data:
- no additional details available
Applicant's summary and conclusion
- Conclusions:
- Not irritating
- Executive summary:
The eye irritation potential of test item was investigated in New Zealand rabbits; the study was conducted according to the OECD guideline 405. Test item was administrated undiluted, 0.1 ml per eye. The substance was indicated to be not eye irritating.
Conclusion
Not irritating
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