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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1986

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Fluorescent Brightener 121
IUPAC Name:
Fluorescent Brightener 121

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
other: sesame oil
Details on oral exposure:
- Concentration vehicle: 20 %
Doses:
2000 mg/kg bw

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
not determinable due to absence of adverse toxic effects
Mortality:
No lethality at 2000 mg/kg bw.
Clinical signs:
No symptoms at 2000 mg/kg bw.

Applicant's summary and conclusion

Interpretation of results:
other: not classified, according to the CLP Regulation (EC) No 1272/2008
Conclusions:
LD50 (male and female) > 2000 mg/kg bw
Executive summary:

Male and female Wistar rats were treated with test item, by oral administration, at a dosage of 2000 mg/kg body weight. The test was conducted according to tyhe OECD guideline 401. The test item was diluted in vehicle (sesame oil 20 %). No lethality and symptoms were recorded at 2000 mg/kg bw.

Conclusion

LD50 (male and female) > 2000 mg/kg bw