Resinoid of Myroxylon balsamum var. pereirae (Fabaceae) obtained from the exudate by ethanol extraction

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

20 November 2017 - 01 December 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

The study was conducted according to an internationally recognised method, and under GLP. The test substance is adequately characterised. Therefore full validation applies.

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Version / remarks:

1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Version / remarks:

2008

Deviations:

no

Principles of method if other than guideline:

Not applicable

GLP compliance:

yes (incl. QA statement)

Remarks:

Inspected on 4,5 and 6 July 2016/ Signed on 10 January 2017

Type of method:

differential scanning calorimetry

Key result

Boiling pt.:

250 °C

Atm. press.:

ca. 1 013.25 hPa

Decomposition:

no

First and second determination:

Boiling point was not exploitable due to perturbations on the thermogram. The crucible was visually checked after the determination: The lid hole was obstructed by the test item. By opening the crucible, some test item left in the crucible but no sign of decomposition was observed.

Third determination: (atmospheric pressure: 1017.2 hPa)

Initial boiling point was observed at 250.2°C (onset temperature of the first peak) and a corresponding mass loss was observed on the TG curve, showing that all the substance was evaporated at the end of the study. The crucible was visually checked after the determination: By opening the crucible, no test item left in the crucible and no sign of decomposition was observed.

Fourth determination: (atmospheric pressure: 1017.6 hPa)

Initial boiling point was observed at 250.1°C (onset temperature of the first peak) and a corresponding mass loss was observed on the TG curve, showing that all the substance was evaporated at the end of the study.

The crucible was visually checked after the determination: By opening the crucible, no test item left in the crucible and no sign of decomposition was observed.

In case of small pressure deviations the boiling temperature at standard pressure can be calculated following the equation of Sidney-Young.

T_n= T + (ƒ x ∆p)

With

T_n  = boiling point at 101.325 kPa in K

T    = measured boiling point in K

ƒ    = correction factor (tabulated value)

∆p  = (101.325 – p) kPa

P   = measured atmospheric pressure in kPa

The corrected values following Sidney-Young equation were determined to be 250.0°C (mean of 250.0°C at 1013.25 hPa for the third determination and 249.9°C at 1013.25 hPa for the fourth determination).

Conclusions:

Initial boiling point of test item was determined to be 250.0°C (mean of 250.0°C at 1013.25 hPa for the third determination and 249.9°C at 1013.25 hPa for the fourth determination) and a corresponding mass loss was observed on the TG curve, showing that all the substance was evaporated at the end of the study.
The crucible was visually checked after the determination: By opening the crucible, no test item left in the crucible and no sign of decomposition was observed.

Executive summary:

The study was performed in order to determine the boiling point of test item according to OECD 103, resp. EU A.2, using the DSC method.

Initial boiling point of test item was determined to be 250.0°C (mean of 250.0°C at 1013.25 hPa for the third determination and 249.9°C at 1013.25 hPa for the fourth determination) and a corresponding mass loss was observed on the TG curve, showing that all the substance was evaporated at the end of the study.

The crucible was visually checked after the determination: By opening the crucible, no test item left in the crucible and no sign of decomposition was observed.

Description of key information

Initial boiling point of test item was determined to be 250.0°C (mean of 250.0°C at 1013.25 hPa and 249.9°C at 1013.25 hPa) and a corresponding mass loss was observed on the TG curve, showing that all the substance was evaporated at the end of the study.

The crucible was visually checked after the determination: By opening the crucible, no test item left in the crucible and no sign of decomposition was observed.

Key value for chemical safety assessment

Boiling point at 101 325 Pa:

250 °C

Additional information

A fully reliable experimental study, conducted according to OECD 103/ EU A2 guideline is available.

It is considered as a key study, and the result is retained as key data.