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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Study period:
06 September 1995 to 08 September 1995
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
Deviations:
no
GLP compliance:
yes
Test organisms (species):
Daphnia magna
Test type:
static
Water media type:
freshwater
Total exposure duration:
48 h
Test temperature:
20.0 to 20.6 °C
pH:
6.1 to 8.2
Dissolved oxygen:
> 70 % ASV
Nominal and measured concentrations:
Nominal concentrations of 100, 180, 320, 560 and 1000 mg/L test material in the definitive test
Details on test conditions:
A stock solution was prepared by dissolving a known quantity of the sample in a specified volume of dilution water. Test solutions were prepared by adding the stock solution to the dilution water in appropriate quantities.
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
48 h
Dose descriptor:
other: HNEC
Effect conc.:
560 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Remarks on result:
other: equivalent to 336 mg/L a.i.
Duration:
48 h
Dose descriptor:
LOEC
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Validity criteria fulfilled:
not applicable
Conclusions:
The EC50 (48 h) value was estimated as > 1000 mg/L (equivalent to > 600 a.i./L). The highest NOEC after 48 hours was 560 mg/L (equivalent to 336 mg a.i./L).
Executive summary:

A stock solution was prepared by dissolving a known quantity of the sample in a specified volume of dilution water. Test solutions were prepared by adding the stock solution to the dilution water in appropriate quantities. The EC50 (48 h) value was estimated as > 1000 mg/L (equivalent to > 600 a.i./L). The highest NOEC after 48 hours was 560 mg/L (equivalent to 336 mg a.i./L). The LOEC (48 h) could not be determined because only 5 % immobilisation was observed at the highest test concentration of 1000 mg/L.

Description of key information

The EC50 (48 h) value was estimated as > 1000 mg/L (equivalent to > 600 a.i./L). The highest NOEC after 48 hours was 560 mg/L (equivalent to 336 mg a.i./L).

Key value for chemical safety assessment

Additional information

A stock solution was prepared by dissolving a known quantity of the sample in a specified volume of dilution water. Test solutions were prepared by adding the stock solution to the dilution water in appropriate quantities. The EC50 (48 h) value was estimated as > 1000 mg/L (equivalent to > 600 a.i./L). The highest NOEC after 48 hours was 560 mg/L (equivalent to 336 mg a.i./L). The LOEC (48 h) could not be determined because only 5 % immobilisation was observed at the highest test concentration of 1000 mg/L.