Reaction mass of sodium hydrogen N-(1-oxooctadecyl)-L-glutamate and sodium hydrogen N-(1-oxohexadecyl)-L-glutamate

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

14 May 2008 and 27 June 2008.

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Study conducted in compliance with GLP and agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of relevant results.

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

Date of Signature: 15/10/2007; Date of Inspection: 21/08/2007

Type of method:

effusion method: vapour pressure balance

Temp.:

25 °C

Vapour pressure:

< 0.006 Pa

Transition / decomposition:

no

Run1

Temperature (ºC)	Temperature (K)	Reciprocal Temperature (K^-1)	Mass Difference (µg)	Mass Difference (kg)	Vapour Pressure (Pa)	Log10Vp
40	313.15	0.003193358	6.28	6.280E-09	0.008718249	-2.059570735
41	314.15	0.003183193	7.93	7.930E-09	0.011008872	-1.958257191
42	315.15	0.003173092	6.80	6.800E-09	0.009440142	-2.025021466
43	316.15	0.003163056	7.00	7.000E-09	0.009717793	-2.012432339
44	317.15	0.003153082	7.42	7.420E-09	0.010300861	-1.987126473
45	318.15	0.003143171	6.69	6.690E-09	0.009287434	-2.032104261
46	319.15	0.003133323	7.42	7.420E-09	0.010300861	-1.987126473
47	320.15	0.003123536	7.62	7.620E-09	0.010578512	-1.975575407
48	321.15	0.003113810	8.45	8.450E-09	0.011730765	-1.930673670
49	322.15	0.003104144	8.14	8.140E-09	0.011300405	-1.946905974
50	323.15	0.003094538	8.75	8.750E-09	0.012147242	-1.915522326

No statistical analysis is given due to the nature of the plot

Run 2

Temperature (ºC)	Temperature (K)	Reciprocal Temperature (K^-1)	Mass Difference (µg)	Mass Difference (kg)	Vapour Pressure (Pa)	Log10Vp
40	313.15	0.003193358	6.59	6.590E-09	0.009148608	-2.038644964
41	314.15	0.003183193	5.77	5.770E-09	0.008010238	-2.096354566
42	315.15	0.003173092	5.15	5.150E-09	0.007149519	-2.145723150
43	316.15	0.003163056	5.66	5.660E-09	0.007857530	-2.104713948
44	317.15	0.003153082	4.53	4.530E-09	0.006288801	-2.201432177
45	318.15	0.003143171	5.56	5.560E-09	0.007718704	-2.112455587
46	319.15	0.003133323	5.15	5.150E-09	0.007149519	-2.145723150
47	320.15	0.003123536	5.25	5.250E-09	0.007288345	-2.137371075
48	321.15	0.003113810	6.90	6.900E-09	0.009578968	-2.018681288
49	322.15	0.003104144	7.52	7.520E-09	0.010439687	-1.981312538
50	323.15	0.003094538	6.69	6.690E-09	0.009287434	-2.032104261

No statistical analysis is given due to the nature of the plot

Run 3

Temperature (ºC)	Temperature (K)	Reciprocal Temperature (K^-1)	Mass Difference (µg)	Mass Difference (kg)	Vapour Pressure (Pa)	Log10Vp
40	313.15	0.003193358	4.22	4.220E-09	0.005858441	-2.232217928
41	314.15	0.003183193	5.36	5.360E-09	0.007441053	-2.128365589
42	315.15	0.003173092	2.99	2.990E-09	0.004150886	-2.381859190
43	316.15	0.003163056	3.19	3.190E-09	0.004428537	-2.353739696
44	317.15	0.003153082	4.94	4.940E-09	0.006857986	-2.163803430
45	318.15	0.003143171	6.18	6.180E-09	0.008579423	-2.066541904
46	319.15	0.003133323	4.43	4.430E-09	0.006149975	-2.211126653
47	320.15	0.003123536	3.60	3.600E-09	0.004997722	-2.301227878
48	321.15	0.003113810	3.60	3.600E-09	0.004997722	-2.301227878
49	322.15	0.003104144	4.43	4.430E-09	0.006149975	-2.211126653
50	323.15	0.003094538	5.36	5.360E-09	0.007441053	-2.128365589

No statistical analysis is given due to the nature of the plot

Run 4

Temperature (ºC)	Temperature (K)	Reciprocal Temperature (K^-1)	Mass Difference (µg)	Mass Difference (kg)	Vapour Pressure (Pa)	Log10Vp
40	313.15	0.003193358	5.87	5.870E-09	0.008149064	-2.088892277
41	314.15	0.003183193	5.87	5.870E-09	0.008149064	-2.088892277
42	315.15	0.003173092	2.78	2.780E-09	0.003859352	-2.413485583
43	316.15	0.003163056	5.36	5.360E-09	0.007441053	-2.128365589
44	317.15	0.003153082	4.63	4.630E-09	0.006427626	-2.191949388
45	318.15	0.003143171	2.78	2.780E-09	0.003859352	-2.413485583
46	319.15	0.003133323	4.84	4.840E-09	0.006719160	-2.172685017
47	320.15	0.003123536	3.91	3.910E-09	0.005428082	-2.265353621
48	321.15	0.003113810	4.53	4.530E-09	0.006288801	-2.201432177
49	322.15	0.003104144	3.50	3.500E-09	0.004858897	-2.313462334
50	323.15	0.003094538	4.12	4.120E-09	0.005719616	-2.242633163

No statistical analysis is given due to the nature of the plot

Run 5

Temperature (ºC)	Temperature (K)	Reciprocal Temperature (K^-1)	Mass Difference (µg)	Mass Difference (kg)	Vapour Pressure (Pa)	Log10Vp
40	313.15	0.003193358	7.31	7.310E-09	0.010148153	-1.993613002
41	314.15	0.003183193	3.40	3.400E-09	0.004720071	-2.326051462
42	315.15	0.003173092	4.33	4.330E-09	0.006011149	-2.221042482
43	316.15	0.003163056	2.68	2.680E-09	0.003720527	-2.429395585
44	317.15	0.003153082	3.71	3.710E-09	0.005150430	-2.288156469
45	318.15	0.003143171	3.60	3.600E-09	0.004997722	-2.301227878
46	319.15	0.003133323	2.99	2.990E-09	0.004150886	-2.381859190
47	320.15	0.003123536	3.71	3.710E-09	0.005150430	-2.288156469
48	321.15	0.003113810	4.12	4.120E-09	0.005719616	-2.242633163
49	322.15	0.003104144	5.05	5.050E-09	0.007010694	-2.154239001
50	323.15	0.003094538	4.33	4.330E-09	0.006011149	-2.221042482

No statistical analysis is given due to the nature of the plot

Run 6

Temperature (ºC)	Temperature (K)	Reciprocal Temperature (K^-1)	Mass Difference (µg)	Mass Difference (kg)	Vapour Pressure (Pa)	Log10Vp
40	313.15	0.003193358	3.50	3.500E-09	0.004858897	-2.313462334
41	314.15	0.003183193	2.57	2.570E-09	0.003567818	-2.447597255
42	315.15	0.003173092	8.03	8.030E-09	0.011147697	-1.952814833
43	316.15	0.003163056	3.19	3.190E-09	0.004428537	-2.353739696
44	317.15	0.003153082	3.71	3.710E-09	0.005150430	-2.288156469
45	318.15	0.003143171	2.68	2.680E-09	0.003720527	-2.429395585
46	319.15	0.003133323	4.74	4.740E-09	0.006580334	-2.181752037
47	320.15	0.003123536	3.81	3.810E-09	0.005289256	-2.276605403
48	321.15	0.003113810	3.30	3.300E-09	0.004581245	-2.339016439
49	322.15	0.003104144	4.33	4.330E-09	0.006011149	-2.221042482
50	323.15	0.003094538	3.40	3.400E-09	0.004720071	-2.326051462

No statistical analysis is given due to the nature of the plot

No statistical analyses were performed because the balance readings were too low and variable for a line of best fit to have any meaning. Instead it was considered more appropriate to impose a regression slope on a chosen data point to provide an estimate of the maximum value for the vapour pressure at 25ºC.

Run 6 was chosen because the sample had been under vacuum for the longest period prior to this run and so degassing would have been the most complete. The reading at 42ºC (315.15 K) was chosen because this is the data point which gives the highest estimated vapour pressure at any given temperature when a slope of –1500 K is imposed upon it.

The value of –1500 K is an in-house value and is the shallowest slope observed whilst determining the vapour pressure on a wide range of samples using the vapour pressure balance method. Extrapolation to 25ºC gave a vapour pressure of 5.968 x 10^-3 Pa which has been taken as a maximum for this material.

The test material did not change in appearance under the conditions used in the determination.

Conclusions:

The vapour pressure of the test material has been determined to be less than 6.0 x 10^-3 Pa at 25 °C.

Executive summary:

The vapour pressure of the test material was determined using a vapour pressure balance with measurements being made at several temperatures and linear regression analysis used to calculate the vapour pressure at 25°C. Testing was conducted using Method A4 of Commission Directive 92/69/EEC (which constitutes Annex V of Council Directive 67/548/EEC).The vapour pressure of the test material has been determined to be less than 6.0 x 10 ^-3 Pa at 25ºC.

Description of key information

Vapour Pressure 6E-03 Pa at 25 °C, EU Method A.4, Tremain (2008)

Key value for chemical safety assessment

Vapour pressure:

0.006 Pa

at the temperature of:

25 °C

Additional information

The vapour pressure of the test material was determined in the key study (Tremain 2008), which was conducted in accordance with the guideline EU Method A.4 under GLP conditions. The study was performed using the vapour pressure balance test. The study was assigned a reliability score of 1 in accordance with the principles for assessing data quality as defined in Klimisch et al. (1997).

Under the conditions of the test, the vapour pressure of the test material was determined to be 6E-03 Pa at 25 °C.