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Diss Factsheets
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EC number: 936-610-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 May 2013 to 31 May 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in compliance with GLP and agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of relevant results.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Radiolabelling:
- no
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: Merck-Hitachi LaChrom HPLC system
- Type, material and dimension of analytical (guard) column: LiChrospher CN 100A 250 × 4 mm, 5 μm
- Detection system: UV at 195, 215 and 254 nm
MOBILE PHASES
- Type: Acetonitrile:buffer = 6:4
- pH: 5.4
- Solutes for dissolving test and reference substances: Reference substances were dissolved in acetonitrile except the sodium nitrate. These stock solutions were diluted with eluent. Test material was dissolved in acetonitrile:water (6:4). This stock solution was diluted with eluent.
DETERMINATION OF DEAD TIME
- Method: by inert substances which are not retained by the column (sodium nitrate solution)
REFERENCE SUBSTANCES
- Identity: Sodium nitrate, Acetanilide, Methyl benzoate, Triazophos, Naphthalene, Fenthion and α-Endosulfan
DETERMINATION OF RETENTION TIMES
- Quantity of test material introduced in the column: 10 µg/mL (20 µL injection volume)
- Quantity of reference substances: 10 µg/mL (20 µL injection volume)
REPETITIONS
- Number of determinations: The three calibration series and three test material series were measured alternately (two replicate injections per series).
EVALUATION
- Calculation of capacity factor k': k' =( tR - t0) / t0
- Calculation of retention times: Three series of the reference solutions and the test material were measured alternately. For the determination of the dead time t0 (t0 = retention time of the unretarded component) sodium nitrate solution was injected. The retention times were determined.
- Determination of the log Koc value: The adsorption coefficient Koc was based on the calibration curve prepared by plotting log k' versus log Koc. The capacity factors (k’) were calculated from the dead time and retention times of the reference substances. The log k’ data of the reference substances were plotted against their log Koc values. - Type:
- Koc
- Value:
- < 9.1
- Remarks on result:
- other: The test material elutes with retention time of 1.57 minutes, before the first reference material; therefore the calibration cannot be applied.
- Type:
- log Koc
- Value:
- < 0.97
- Remarks on result:
- other: The test material elutes with retention time of 1.57 minutes, before the first reference material; therefore the calibration cannot be applied.
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration: Sodium nitrate 1.56 minutes, Acetanilide 2.76 minutes, Methyl benzoate 3.10 minutes, Triazophos 3.49 minutes, Naphthalene 3.57 minutes, Fenthion 3.77 minutes and α-Endosulphan 4.16 minutes.
- Details of fitted regression line (log k' vs. log Koc): The equation of the curve fitted to the calibration plot is:
log k' = 0.1145 × log Koc - 0.2262 (r² = 0.9611)
- Graph of regression line attached
- Average retention data for test material: 1.57 minutes - Validity criteria fulfilled:
- not applicable
- Remarks:
- the substance meets the specification for which the method is validated
- Conclusions:
- Under the conditions of the test, the test material eluted with a retention time of 1.57 minutes. This was less than the retention time of the first reference substance. Therefore calculation of the logKoc and Koc was not possible.
An accurate adsorption coefficient could not be determined, however it was concluded that the logKoc and Koc are lower than 0.97 and 9.1, respectively (the logKoc and Koc of the first reference substance). - Executive summary:
The adsorption coefficient of the test material was investigated using the HPLC method in accordance with the standardised guidelines OECD 121 and EU Method C.19. The study was performed under GLP conditions.
The study was carried out using an HPLC system with UV detection. The mobile phase was acetonitrile:buffer (pH 5.4) 6:4. The reference substances used to create the calibration curve were Sodium nitrate, Acetanilide, Methyl benzoate, Triazophos, Naphthalene, Fenthion and α-Endosulfan.
Under the conditions of the test, the test material eluted with a retention time of 1.57 minutes. This was less than the retention time of the first reference substance. Therefore calculation of the logKoc and Koc was not possible.
An accurate adsorption coefficient could not be determined, however it was concluded that the logKoc and Koc are lower than 0.97 and 9.1, respectively (the logKoc and Koc of the first reference substance).
Reference
Description of key information
Koc < 9.1 and logKoc < 0.97 (could not be accurately determined due to the low retention time), EU Method C.19, OECD 121, Szabo (2013)
Key value for chemical safety assessment
- Koc at 20 °C:
- 9.1
Additional information
In the key study (Szabo 2013), the adsorption coefficient of the test material was investigated using the HPLC method in accordance with the standardised guidelines OECD 121 and EU Method C.19. The study was performed under GLP conditions. The study was therefore assigned a reliability score of 1 in accordance with the principles for assessing data quality as defined in Klimisch et al. (1997).
The study was carried out using an HPLC system with UV detection. The mobile phase was acetonitrile:buffer (pH 5.4) 6:4. The reference substances used to create the calibration curve were Sodium nitrate, Acetanilide, Methyl benzoate, Triazophos, Naphthalene, Fenthion and α-Endosulfan.
Under the conditions of the test, the test material eluted with a retention time of 1.57 minutes. This was less than the retention time of the first reference substance. Therefore calculation of the logKoc and Koc was not possible.
An accurate adsorption coefficient could not be determined, however it was concluded that the logKoc and Koc are lower than 0.97 and 9.1, respectively (the logKoc and Koc of the first reference substance).
[LogKoc: 0.97]
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