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Short-term toxicity to aquatic invertebrates

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Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
1. SOFTWARE
OECD Toolbox Version 3.4

2. SMILES
Isomer 1, 5-Methacryloyloxy-1,3-dioxan : C=C(C)C(OC1COCOC1)=O
Isomer 2 4-Methacryloyloxymethyl-1,3-dioxolan : C=C(C)C(OCC1OCOC1)=O
Guideline:
other: REACH Guidance on QSARs
Specific details on test material used for the study:
SMILES
Isomer 1, 5-Methacryloyloxy-1,3-dioxan : C=C(C)C(OC1COCOC1)=O
Isomer 2 4-Methacryloyloxymethyl-1,3-dioxolan : C=C(C)C(OCC1OCOC1)=O
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
314 mg/L
Basis for effect:
mortality
Remarks on result:
other: prediction for both isomers

Toxicity of the target chemical (314 mg/L) is predicted from category members using trend analysis based on 11 values within the range 2.57 - 380 mg/L from 11 category members. Category members are single

chemicals or mixtures and are selected based on the profile of the target chemical. Only chemicals having experimental data are listed in the category.

The target chemical FALLS within applicability domain of the prediction.

The data used for calculating the current prediction is taken from 11 experimental values selected from the following database(s):

1. ECHA CHEM (Company is owner of the data)

Validity criteria fulfilled:
yes
Remarks:
The target chemical FALLS within applicability domain of the prediction
Conclusions:
EC50 Daphnia magna of Glycerolformal methacrylate (both isomers) is 314 mg/l based on QSAR predicted from category members using trend analysis based on 11 values within the range 2.57 - 380 mg/L from 11 category members. Category members are single
chemicals or mixtures and are selected based on the profile of the target chemical. Only chemicals having experimental data are listed in the category.
Executive summary:

EC50 Daphnia magna of Glycerolformal methacrylate (both isomers) is 314 mg/l based on QSAR predicted from category members using trend analysis based on 11 values within the range 2.57 - 380 mg/L from 11 category members. Category members are single chemicals or mixtures and are selected based on the profile of the target chemical. Only chemicals having experimental data are listed in the category.

Description of key information

EC50 (48h) Daphnia magna: 314 mg/l based on QSAR prediction.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
314 mg/L

Additional information