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EC number: 616-105-5
CAS number: 74504-65-7
No data are available on Polyglycerol-2-caprate on acute toxicity
by dermal exposure. Data were therefore obtained for the group of
polyglyceryl fatty acid esters, the relevant hydrolysis products as well
as the components in the UVCB substance.
In the evaluation of polyglyceryls by CIR (2016), one study on
acute toxicity by dermal route is reported. The study is performed on
Wistar rats and 5 g/kg (5.2 mL/kg bw) was applied with a semi-occlusive
patch for 24 h. An LD50of >5000 mg/kg was found and no local
effects were observed (CIR 2016).
QSAR estimations support the low dermal toxicity with LD50 values
in the range of 2200-2500 mg/kg/d for subcutaneous administration of the
decanoic monoester of glyceryl and the dilaurate ester with diglyceryl.
As the Polyglycerol-2-caprate is expected to hydrolyse upon skin
penetration, it is also relevant to consider decanoic acid being
administrated by the subcutaneous exposure route. The LD50 is estimated
to be 3500 mg/kg/d.
The dermal toxicity of the other constituents in the UVCB
substance, diglycerol and triglycerol, is estimated with LD50 values of
5500 mg/kg/d and above.
Based on the studies available in the present analysis it is
concluded that the NOAEL for compoundPolyglycerol-2-capratein regards to
dermal toxicity is expected to be > 2200 mg/kg day.
Polyglycerol-2-caprate should not be classified for acute dermal
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