Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

basic toxicokinetics, other
Type of information:
other: weight of evidence assessment based on hydrolysis products and structural analogues
Adequacy of study:
weight of evidence
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
Justification for type of information:
No data is available for polyglycerol-2-caprate. The toxicokinetics of this substance is therefore assessed in a weight of evidence analysis based on existing data on similar compounds.

Data source

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Decanoic acid, 3-(2,3.dihydroxypropoxy)-2-hydroxypropyl ester
EC Number:
Cas Number:
Molecular formula:
Decanoic acid, 3-(2,3.dihydroxypropoxy)-2-hydroxypropyl ester

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on absorption:
Polyglycerol-2-caprate is hydrolysed in the stomach and in the intestine and is readily absorbed.
Details on distribution in tissues:
The majority of polyglycerol-2-caprate is distributed to the liver where it is further utilized.
Details on excretion:
Polyglycerol-2-caprate is excreted in the urine and feces, however, a large proportion is utilized and excreted as CO2

Metabolite characterisation studies

Details on metabolites:
The major hydrolysis products are glycerol and decanoic acid

Applicant's summary and conclusion

Polyglycerol-2-caprate is hydrolysed and absorbed efficiently in the stomach and in the intestines and metabolised primarily in the liver.
Executive summary:

No data exist on the toxicokinetics ofpolyglycerol-2-caprate, however, several data exist on the toxicokinetics of the polyglyceryls and the hydrolysis product decanoic acid. Documentation that polyglycerol fatty acid esters are hydrolysed and absorbed efficiently in the stomach and in the intestines exists and data show that fatty acids are readily absorbed and metabolised in the liver.

Asthe main constituent of polyglycerol-2-caprate is diglycerol and decanoic acid, the toxixcokinetics can be expected to be similar to what is described above.