Registration Dossier
Registration Dossier
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EC number: 202-711-3 | CAS number: 98-89-5
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Type of information:
- (Q)SAR
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: The study results are disregarded as the substance is out of the the Applicability Domain (AD) of the model.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- publication
- Title:
- Skin Sensitisation model (CAESAR) (version 2.1.3)
- Author:
- Laboratory of Environmental Chemistry and Toxicology of Mario Negri Institute of Pharmacological Research.
- Bibliographic source:
- VegaNIC v.1.0.6
- Report date:
- 2013
Materials and methods
Test guideline
- Guideline:
- other: REACH guidance on QSARs R6, May 2008
- Principles of method if other than guideline:
- General model for estimating the skin sensitisation.
Test material
- Reference substance name:
- Cyclohexanecarboxylic acid
- EC Number:
- 202-711-3
- EC Name:
- Cyclohexanecarboxylic acid
- Cas Number:
- 98-89-5
- Molecular formula:
- C7H12O2
- IUPAC Name:
- cyclohexanecarboxylic acid
- Details on test material:
- General model for estimating the skin sensitisation.
Constituent 1
In vivo test system
Test animals
- Details on test animals and environmental conditions:
- SMILE:OC(=O)C1CCCCC1
InChI=1/C7H12O2/c8-7(9)6-4-2-1-3-5-6/h6H,1-5H2,(H,8,9)
Results and discussion
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The prediction indicates that the substance is sensitizer.The obtained results are disregarded as the substance is out from the applicability domain of the model.
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