Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
1986
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The data obtained from a source of secondary literature are related to a substance which shows the same functional groups . The data derived from read-across is considered reliable because the molecules have the same functional groups due to the action irritating.
Qualifier:
no guideline available
Principles of method if other than guideline:
no data
GLP compliance:
no
Species:
rabbit
Strain:
not specified
Type of coverage:
not specified
Controls:
not specified
Irritation parameter:
other: REACTION: Severe
Irritant / corrosive response data:
REACTION: Severe
Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
According to Directive 67/548/EEC and to Regulation (EC) n. 1272/2008, the substance is classified for this property.
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

According to Directive 67/548/EEC and to Regulation (EC) n. 1272/2008, the substance is classified as irritant.


Justification for selection of skin irritation / corrosion endpoint:
The data obtained from a source of secondary literature are related to a substance which shows the same functional groups . The data derived from read-across is considered reliable because the molecules have the same functional groups due to the action irritating.

Effects on skin irritation/corrosion: irritating

Justification for classification or non-classification

According to Directive 67/548/EEC and to Regulation (EC) n. 1272/2008, the substance is classified as irritant.