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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
sieving
Type of particle tested:
primary particle
Type of distribution:
mass based distribution
Mass median aerodynamic diameter:
60.51 µm
No.:
#1
Size:
>= 10 - <= 100 µm
Distribution:
100 %
Remarks on result:
other: sieve fraction nominal < 100 µm

Result: Sieve Fraction (< 100 µm):

weighted sample: 1.0132 g

weight fraction < 100 µm: 0.1356 g

mass fraction < 100 µm: 13.38 %

Statistical Data Sieve Fraction:

 Counts  1287  
   Mean diameter [µm]  Aspect Ratio
 Minimum  11.30  1.04
 Maximum  99.75  5.43
 Arithmetic mean  43.27  1.65
 Median  40.09  1.56
 Standard deviation  20.01  0.45

Statistical Data Mass Fraction:

 Particle Size  Sperical Volume [%]  Cubical Volume [%]
 < 4 µm (respirable)  0.00  0.00
 4 -10 µm (thoracic)  0.00  0.00
 10 -100 µm (inhalative)  100.00  100.00
 > 100 µm  0.00  0.00
 Median (diameter µm)  60.51  57.91

Conclusion:

Accounting based on total sample weight

   Particle Size [µm]  Spherical Volume [%]
 Mass Fraction  > 100  86.62
 Sieve Fraction  > 100  0.00
 Total (> 100 µm)    86.62
 Sieve Fraction  10 -100 (inhalative)  13.38
 Sieve Fraction  4 -10 (thoracic)  0.00
 Sieve Fraction  < 4 (respirable)  0.00
Conclusions:
The MMAD (Mass Median Aerodynamic Diameter < 100 μm) of the test item has a value of 60.51 μm as spherical particles.
Executive summary:

Determination of the particle size distribution of the test item was determined by scanning electron microscopy after the samples was fractionated by a 100 μm sieve following OECD Guidelines No: 110 method B. For the determination of the particle size and the aspect ratio, 6 pictures have been taken by SEM (scanning electron microscope) at a magnification of 50 times. The MMAD (Mass Median Aerodynamic Diameter < 100 μm) has a value of 60.51 μm as spherical particles.

Description of key information

The MMAD (Mass Median Aerodynamic Diameter < 100 μm) of the test item has a value of 60.51 μm as spherical particles.

Additional information

Determination of the particle size distribution of the test item was determined by scanning electron microscopy after the samples was fractionated by a 100 μm sieve following OECD Guidelines No: 110 method B. For the determination of the particle size and the aspect ratio, 6 pictures have been taken by SEM (scanning electron microscope) at a magnification of 50 times. The MMAD (Mass Median Aerodynamic Diameter < 100 μm) has a value of 60.51 μm as spherical particles.