Bis(O,O-diisopropyl dithiophosphate)bis(cyclohexylamine) zinc

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

03 Jun - 20 Sep 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Remarks:

Flask method (modified procedure)

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

adopted in 1995

GLP compliance:

yes (incl. QA statement)

Remarks:

Ministerium für Arbeit, Integration und Soziales des Landes Nordrhein-Westfalen, Düsseldorf, Germany

Type of method:

flask method

Specific details on test material used for the study:

Storage conditions: at room temprature, tightly closed, dry

Water solubility:

10.2 g/L

Conc. based on:

element

Remarks:

phosphorus

Temp.:

23 °C

pH:

>= 6.2 - <= 6.9

Water solubility:

9.7 g/L

Conc. based on:

element

Remarks:

sulphur

Temp.:

23 °C

pH:

>= 6.2 - <= 6.9

Water solubility:

0.029 g/L

Conc. based on:

element

Remarks:

zinc

Temp.:

23 °C

pH:

>= 6.2 - <= 6.9

Results of the P-analysis:

Sample no.	Amount of test item [g]	Added volume of water [mL]	Shaking time at 30°C [h]	Dilution factor	Analysed concentration of P [mg/L]	Mean value P [g/L]	pH value^1)
1	0.5156	50	72	1000	0.707142	0.74	6.9
2	0.5031		72	1000	0.779720
3	0.5005		96	1000	0.794127	0.81	6.7
4	0.5140		96	1000	0.822756
5	0.5051		120	1000	0.827194	0.83	6.2
6	0.5023		120	1000	0.841795

¹⁾   The purified water used for the tests had a pH of 5.5.

The mean value of the samples after 120 h did not exceed the mean values of the sample after 96 h and 72 h by more than 15 %. So, the three duplicate sets of samples showed no tendency of increasing concentration values.

Water solubility mean value P samples 1 - 6  [g/L]	Standard deviation  [g/L]	Rel. standard deviation [%]	Water solubility mean value test item [g/L]*
8.0 x 10^-1	4.9 x 10^-2	6.2	10.2

*calculated with the content of the neat test item given by the study monitor: 7.83 %

The relative standard deviation did not exceed 15 %. Therefore, the tests were valid.

Results of the S-analysis:

Sample no.	Amount of test item [g]	Added volume of water [mL]	Shaking time at 30°C [h]	Dilution factor	Analysed concentration of S [mg/L]	Mean value S [g/L]	pH value^1)
1	0.5156	50	72	1000	1.47341	1.54	6.9
2	0.5031		72	1000	1.60410
3	0.5005		96	1000	1.64377	1.67	6.7
4	0.5140		96	1000	1.70024
5	0.5051		120	1000	1.70996	1.73	6.2
6	0.5023		120	1000	1.75470

¹⁾     The purified water used for the tests had a pH of 5.5.

The mean value of the samples after 120 h did not exceed the mean values of the sample after 96 h and 72 h by more than 15 %. So, the three duplicate sets of samples showed no tendency of increasing concentration values.

Water solubility mean value S samples 1 - 6  [g/L]	Standard deviation  [g/L]	Rel. standard deviation [%]	Water solubility mean value test item [g/L]*
1.6	1.0 x 10^-1	6.1	9.7

*calculated with the content of the neat test item given by the study monitor: 16.52 %

The relative standard deviation did not exceed 15 %. Therefore, the tests were valid.

 

Results of the Zn-analysis:

Sample no.	Amount of test item [g]	Added volume of water [mL]	Shaking time at 30°C [h]	Dilution factor	Analysed concentration of Zn [mg/L]	Mean value Zn [g/L]	pH value^1)
1	0.5156	50	72	-	2.49710	0.0024	6.9
2	0.5031		72	-	2.34973
3	0.5005		96	-	2.54903	0.0026	6.7
4	0.5140		96	-	2.61292
5	0.5051		120	-	2.71764	0.0027	6.2
6	0.5023		120	-	2.70537

¹⁾     The purified water used for the tests had a pH of 5.5.

The mean value of the samples after 120 h did not exceed the mean values of the sample after 96 h and 72 h by more than 15 %. So, the three duplicate sets of samples showed no tendency of increasing concentration values.

Water solubility mean value Zn samples 1 - 6  [g/L]	Standard deviation  [g/L]	Rel. standard deviation [%]	Water solubility mean value test item [g/L]*
2.6 x 10^-3	1.4 x 10^-4	5.4	2.9 x 10^-2

*calculated with the content of the neat test item given by the study monitor: 9.04 %.

The relative standard deviation did not exceed 15 %. Therefore, the tests were valid.

Summary of the results (at 23 °C; pH 6.2 – 6.9):

Water solubility (samples 1-6)	Mean value [g test item/L]
Evaluation based on phosphorus-analysis	10.1
Evaluation based on sulphur-analysis	9.7
Evaluation based on zinc-analysis	2.9 x 10^-2

 

The clear difference of the water solubility results depending on the respective element used for analysis (phosphor and sulphur compared with zinc: factor approx.100) indicated, that the test item decomposed (at least in parts) in soluble and insoluble compounds or due to formation of complexes.

This may probably due to hydrolysis of the test item during the experimental procedure.

Description of key information

Evaluation based on phosphorus-analysis: 10.2 g/L

Evaluation based on sulphur-analysis: 9.7 g/L

Evaluation based on zinc-analysis: 2.9E-02 g/L

at 23 °C; pH 6.2 - 6.9

(OECD 105, flask method)

Key value for chemical safety assessment

Water solubility:

10.2 g/L

at the temperature of:

20 °C

Additional information

The key value of water solubility for chemical safety assessment was based on the phosphorus analysis, because the solubility of test substance in n-octanol was also based on the phosphorus analysis.