Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 809-986-4 | CAS number: 52585-16-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25 Oct - 08 Nov 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- adopted 24 Feb 1987
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- The Department of Health of the Government of the United Kingdom, UK
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- O,O-bis(propan-2-yl) [({[bis(propan-2-yloxy)(sulfanylidene)-λ⁵-phosphanyl]sulfanyl}bis(cyclohexylazaniumyl)zinciodiuide)sulfanyl]phosphonothioate
- EC Number:
- 809-986-4
- Cas Number:
- 52585-16-7
- Molecular formula:
- C24H54N2O4P2S4Zn
- IUPAC Name:
- O,O-bis(propan-2-yl) [({[bis(propan-2-yloxy)(sulfanylidene)-λ⁵-phosphanyl]sulfanyl}bis(cyclohexylazaniumyl)zinciodiuide)sulfanyl]phosphonothioate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- RccHan™:WIST
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Envigo RMS (UK), Limited, Oxon, UK
- Females nulliparous and non-pregnant: yes
- Age at study initiation: 8 - 12 weeks
- Weight at study initiation: 227 - 249 g (males); 209 - 221 g (females)
- Housing: The animals were housed individually during the exposure period and in groups of 5 animals per sex in suspended solid floor polypropylene cages furnished with woodflakes.
- Diet: 2014C Teklad Global Rodent diet (Envigo RMS (UK) Limited, Oxon, UK), ad libitum
- Water: Trinking water, ad libitum
- Acclimation period: At least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 - 25
- Humidity (%): 30 - 70
- Air changes (per hr): At least 15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- DMSO
- Remarks:
- as moistener
- Details on dermal exposure:
- TEST SITE
- Area of exposure: clipped skin of the dorsal area of the trunk
- % coverage: 10
- Type of wrap if used: A piece of surgical gauze was placed over the treatment area and semi-occluded with a piece of self-adhesive bandage. Shortly after dosing the dressings were examined to ensure that they were securely in place.
REMOVAL OF TEST SUBSTANCE
- Washing: Yes, the treated skin and surrounding hair was wiped with cotton wool moistened with DMSO to remove any residual test item.
- Time after start of exposure: 24 h - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw (due to the purity of the test material, the animals were dosed with 2218 mg/kg bw of the test material)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The animals were observed for deaths or overt signs of toxicity 30 min, 1, 2 and 4 h after dosing and thereafter once daily for 14 days. The body weights were determined prior to the treatment and on Days 7 and 14.
- Necropsy of survivors performed: yes
- Other: The test sites were examined for evidence of primary irritation after removal of the test substance and subsequently once daily for 14 days, and scored according to the Draize scoring system.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality observed at the dose level of 2000 mg/kg bw.
- Clinical signs:
- other: There were no systemic clinical signs noted in any animal throughout the study. Very slight erythema (grade 1) was observed at the test sites of all animals up to 5 or 6 days after treatment with the test substance. Crust formation was noted at the test s
- Gross pathology:
- Necropsy revealed no substance-related findings.
Any other information on results incl. tables
Table 1 Individual Dermal Reactions
Males | Day 1 | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | Day 8 | Day 9 - 14 | |
1 | Erythema | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
Other | 0 | 0 | 0 | 0 | 0 | Cf | Cf | 0 | 0 | |
2 | Erythema | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
Other | 0 | 0 | 0 | 0 | 0 | Cf | Cf | 0 | 0 | |
3 | Erythema | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
Other | 0 | 0 | 0 | 0 | 0 | Cf | Cf | Cf | 0 | |
4 | Erythema | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
Other | 0 | 0 | 0 | 0 | 0 | Ss | Ss | Ss | Ss | |
5 | Erythema | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
Other | 0 | 0 | 0 | 0 | 0 | Cf | Cf | Cf | 0 | |
Females | ||||||||||
1 | Erythema | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
Other | 0 | 0 | 0 | 0 | 0 | Cf | Cf | 0 | 0 | |
2 | Erythema | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
Other | 0 | 0 | 0 | 0 | 0 | Cf | Cf | 0 | 0 | |
3 | Erythema | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
Other | 0 | 0 | 0 | 0 | 0 | Cf | Cf | Cf | 0 | |
4 | Erythema | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
Other | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
5 | Erythema | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Other | 0 | 0 | 0 | 0 | 0 | Cf | Cf | 0 | 0 |
0 = No reaction
Cf = Crust formation
Ss = Small superficial scattered scabs
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met; no classification required according to Regulation (EC) No. 1272/2008
- Conclusions:
- CLP: not classified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
