2-[bis(2-hydroxyethyl)amino]ethanesulphonic acid

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

Acute, single dose

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

The substance is based on the natural amino acid taurine, but instead of having a primary amine, the amine is tertiary, with two ethanol groups.
Taurine is well evaluated as being of low hazard, but it is necessary to confirm that tertiary amines with ethanol are themselves of low toxicity
This endpoint considers a review by the US National Toxicity Programme.
No further animal testing can be justifed

Data source

Reference

Reference Type:

review article or handbook

Title:

Unnamed

Year:

1999

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Principles of method if other than guideline:

Precise methods not described, but considered valid in the review

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2,2',2''-nitrilotriethanol

EC Number:

203-049-8

EC Name:

2,2',2''-nitrilotriethanol

Cas Number:

102-71-6

Molecular formula:

C6H15NO3

IUPAC Name:

2,2',2''-nitrilotriethanol

Specific details on test material used for the study:

No specific details on purity or source

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

not specified

Doses:

In axcess of 9000 mg/kg

No. of animals per sex per dose:

Not specified

Control animals:

not specified

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD0

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

mortality from 8000 mg/kg

Clinical signs:

Not reported

Gross pathology:

The animals that died had effects gastrointestinal tract and included gastric dilatation, congestion with some hemorrhage in the stomach; these effects were concluded to be local damage and are consistent with other references suggesting toxicity is related to alkalinity.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The substance is of low acute toxicity with effects only seen at exceptionally high treatment levels.
The effects were concluded to be local damage and are consistent with other references suggesting toxicity is related to alkalinity.