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EC number: 206-329-8
CAS number: 328-42-7
The acute toxic class method was
performed according to OECD 423 and Directive 2004/73/EC B.1. tris.
Starting dose was selected on the
basis of the available information about the test item (Preliminary
study: LD50: 2000-5000 mg/kg bw, based on sponsor’s information). The
starting dose was 5000 mg/kg bw. One animal was treated with 5000 mg/kg
bw dose. The first animal died, so dosing was proceeded at 2000 mg/kg bw
in accordance with the flow charts in Annex 2 of the OECD guideline No.
423. Three animals were treated with 2000 mg/kg bw dose. Only one animal
died in the second step at 2000 mg/kg bw dose level, so treatment with
2000 mg/kg bw was repeated on further three female rats. Only one animal
died in the third step, too, so the test was finished, the stopping
criteria of Annex 2d of OECD Guideline No. 423 (presented in Appendix
VII) was met.
were weighed, observed for lethality and toxic symptoms for 14 days
after the treatment. Gross pathological examination was carried out in
animals died on the treatment day, 1st and 2nd day, as well as 15th day
after the treatment in survivor animals.
LD50 value of the test item was between 2000 mg/kg bw and 5000 mg/kg bw.
The test item was ranked into Category 5 of the Globally Harmonized
Classification System (GHS) according to OECD Guideline No. 423, but not determined
to be classfied according to Regulation (EC) No 1272/2008 (CLP).
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