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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2017-08-21 to 2017-09-26
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
yes
Remarks:
refer to 'Principles of method if not a quideline'
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
yes
Remarks:
refer to 'Principles of method if not a quideline'
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Deviations:
yes
Remarks:
refer to 'Principles of method if not a quideline'
Principles of method if other than guideline:
An OECD Preliminary test with visual inspection was performed. Visual inspections were performed after 10 minutes of shaking and after 24 hours of resting of the samples.
GLP compliance:
yes (incl. QA statement)
Type of method:
other: visual inspection
Key result
Water solubility:
> 1 000 g/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
0.57
Details on results:
After 24 hour waiting period the Test Item was completely dissolved in each ratio. The pH value at the Ultrapure Water : Test Item = 5 : 5 ratio was determined to be: 0.57.

Water solubility test after 10 minutes of shaking

Ultrapure Water : Test Item ratio

Observation

5 : 1

clear liquid phase

5 : 2

precipitation of test item

5 : 3

precipitation of test item

5 : 4

precipitation of test item

5 : 5

precipitation of test item

Water solubility test after 24 hours waiting period

Ultrapure Water : Test Item ratio

Observation

5 : 2

clear liquid phase

5 : 3

clear liquid phase

5 : 4

clear liquid phase

5 : 5

clear liquid phase with ca. 3-4 millimeters of foam at the top of the solution

Conclusions:
In conclusion, the water solubility of the test item was determined to be > 1000 g/L at room temperature based on the Preliminary Test (OECD 105).
Executive summary:

The water solubility of the test item was determined according to OECD 105, Regulation (EC) No. 440/2008 method A.6 and OPPTS 830.7840 using the OECD Preliminary test. The test item was mixed with ultrapure water in ratios from 5:1 to 5:5 (5 mL water and 1 to 5 mg test item). After the addition of test substance, the mixtures were shaken for 10 minutes. After shaking, the solutions were checked visually. In the case of Ultrapure Water : Test Item  = 5 : 1 ratio the Test Item was completely dissolved. In the other ratios undissolved test item particles were observed, therefore, the solutions were allowed to stand for 24 hours at room temperature. After 24 hour waiting period the Test Item was completely dissolved in each ratio. The pH value at the Ultrapure Water : Test Item = 5 : 5 ratio was determined to be: 0.57. In conclusion, the water solubility of the test substance was determined to be >1000 g/L at 20 °C ± 1 °C (pH = 0.57).

Description of key information

The water solubility of the test item was determined to be > 1000 g/L at room temperature based on the Preliminary Test (OECD 105).

Key value for chemical safety assessment

Additional information

The water solubility of the test item was determined according to OECD 105, Regulation (EC) No. 440/2008 method A.6 and OPPTS 830.7840 using the OECD Preliminary test (reference 4.8-1). The test item was mixed with ultrapure water in ratios from 5:1 to 5:5 (5 mL water and 1 to 5 mg test item). After the addition of test substance, the mixtures were shaken for 10 minutes. After shaking, the solutions were checked visually. In the case of Ultrapure Water : Test Item  = 5 : 1 ratio the Test Item was completely dissolved. In the other ratios undissolved test item particles were observed, therefore, the solutions were allowed to stand for 24 hours at room temperature. After 24 hour waiting period the Test Item was completely dissolved in each ratio. The pH value at the Ultrapure Water : Test Item = 5 : 5 ratio was determined to be: 0.57. In conclusion, the water solubility of the test substance was determined to be >1000 g/L at 20 °C ± 1 °C (pH <0.57).

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