Registration Dossier
Registration Dossier
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EC number: 235-795-5 | CAS number: 12738-64-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Justification for type of information:
- Study is referenced in OECD SIDS report, ref 73: Angenelli et al 1985
Data source
Reference
- Reference Type:
- other: SISD Assessment report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.1100 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Benzoic acid
- EC Number:
- 200-618-2
- EC Name:
- Benzoic acid
- Cas Number:
- 65-85-0
- Molecular formula:
- C7H6O2
- IUPAC Name:
- benzoic acid
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Details on dermal exposure:
- The test compound was applied once only to a shaved area of the back of each rabbit at a dose of 2000 mg/kg bw.
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg/day
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
- Details on study design:
- The test compound was applied once only to a shaved area of the back of each rabbit at a dose of 2000 mg/kg bw.
The skin of 1 male and 1 female was abraded with a scalpel blade prior to test application.
The area was wrapped with a gauze bandage and occluded with plastic wrap. The bandages were removed and the backs washed
24 hours after application. The rabbits were observed for a period of 14 days.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute dermal toxicity of benzoic acid was determined according to the method EPA OTS 798.1100. LD50 of benzoic acid was found to be > 2000 mg/kg/day for acute dermal toxicity
- Executive summary:
The acute dermal toxicity of benzoic acid was determined according to the method EPA OTS 798.1100.
The test compound was applied once only to a shaved area of the back of each rabbit at a dose of 2000 mg/kg bw. The skin of 1 male and 1 female was abraded with a scalpel blade prior to test application. The area was wrapped with a gauze bandage and occluded with plastic wrap. The bandages were removed and the backs washed
24 hours after application. The rabbits were observed for a period of 14 days.
LD50 was found to be > 2000 mg/kg/day for acute dermal toxicity
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