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Diss Factsheets
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EC number: 202-675-9 | CAS number: 98-51-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data are given.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicological studies on p-tertiary-butyltoluene.
- Author:
- Hine CH et al.
- Year:
- 1 954
- Bibliographic source:
- AMA Arch Ind Hyg Occup Med 9: 227-244.
Materials and methods
- Principles of method if other than guideline:
- Draize Test according to
- Draize JH et al (1944). Methods for the Study of Irritation and Toxicity of Substances Applied Topically to the Skin and Mucous Membranes. J Pharm Exp Ther 82:377-390.
- Carpenter CP and Smyth HF Jr (1946). Chemical Burns of the Rabbit Cornea. Am J Ophth 29: 1363-1372. - GLP compliance:
- no
- Remarks:
- pre-GLP study
Test material
- Reference substance name:
- 4-tert-butyltoluene
- EC Number:
- 202-675-9
- EC Name:
- 4-tert-butyltoluene
- Cas Number:
- 98-51-1
- Molecular formula:
- C11H16
- IUPAC Name:
- 1-tert-butyl-4-methylbenzene
- Details on test material:
- - Name of test material (as cited in study report): p-tertiary-butyltoluene
- Physical state: liquid with distinct odour
- Analytical purity: no data
No further data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no further data on animals and environmental conditions
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- no details given
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): no details given
VEHICLE : no data - Duration of treatment / exposure:
- unspecified
- Observation period (in vivo):
- no data
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data
SCORING SYSTEM: Draize system
TOOL USED TO ASSESS SCORE: no data
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- of n=6
- Time point:
- other: 1 h
- Score:
- 9.3
- Remarks on result:
- other: Draize method
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- of n=6
- Time point:
- other: 72 h
- Score:
- 4
- Remarks on result:
- other: Draize method
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- of n=6
- Time point:
- other: 24 h
- Score:
- 6.6
- Remarks on result:
- other: Draize method
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- of n=6
- Time point:
- other: no data
- Score:
- < 1
- Remarks on result:
- other: method of Carpenter and Smyth
- Irritant / corrosive response data:
- The most consistent sign of eye irritation was a moderate to heavy discharge from the treated eyes. A slight chemosis was evident at the 24-hour point, but it had disappeared before the time of the 48-hour reading. According to Draize's method, the average total scores were 9.3 (1 h), 6.6 (24 h), and 4.0 (72 h) (maximum score = 110). According to the method of Carpenter and Smyth, the grade of irritation was less than 1.
According to the authors, these classifications indicate only a moderate irritation of the conjunctivae.
No further data. - Other effects:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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