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Diss Factsheets
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EC number: 233-487-5 | CAS number: 10196-49-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Version / remarks:
- adopted July 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- Version / remarks:
- 2008
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Purity : 98.6 %
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- Origin : aeration tank of a wastewater plant treating predominantly domestic sewage (Wupper area water authority, WWTP Odenthal)
Date of collection : 2016-10-04
Concentration of inoculum : 30 mg/L suspended solids - Duration of test (contact time):
- 28 d
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Remarks:
- BOD
- Details on study design:
- A suspension of 100 mg/L test item in a mineral medium, equalling to 50-100 mg ThOD or COD/Litre as the nominal sole source of organic carbon, was stirred in a closed flask and inoculated at a constant temperature (22 ± 1 °C) for up to 28 days under aerobic conditions in the dark.
The consumption of oxygen (BOD) was determined by measuring the drop in pressure in the automated respirometer flasks. Evolved carbon dioxide was absorbed in sodium hydroxide. The amount of oxygen taken up by the test item (corrected for uptake by blank inoculum, run in parallel) was expressed as a percentage of theoretical oxygen demand (ThOD).
The endogenous activity of the inoculum was checked running parallel blanks with inoculum but without test item. A reference compound (sodium benzoate) was run in parallel to check the operation of the procedures.
A toxicity control (test item and reference compound mixed, one replicate) was run in parallel, to ensure that the chosen concentration of the test item was not inhibitory to microorganisms.
Degradation was followed by the determination of oxygen uptake and measurements were taken at frequent intervals to allow the identification of the beginning and end of biodegradation and the slope of the biodegradation curve.
Because of the nature of biodegradation and of the mixed bacterial populations used as inoculum, determinations of test item and inoculum blank were carried out in triplicate and of reference compound in duplicate.
The oxygen uptake was calculated from the readings taken at regular and frequent intervals, using the method given by the manufacturer of the equipment. At the end of incubation, the pH was measured in the flasks.
Start of the incubation period : 2016-10-05
End of the incubation period : 2016-11-03 - Reference substance:
- benzoic acid, sodium salt
- Remarks:
- Reference compound name : sodium benzoate (Acros Organics) Coding number : Ökotox_7/02 Purity : 99.9 % Expiry date : 2018-03-27
- Parameter:
- % degradation (O2 consumption)
- Value:
- 1
- Sampling time:
- 7 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 1
- Sampling time:
- 14 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 2
- Sampling time:
- 21 d
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 3
- Sampling time:
- 28 d
- Parameter:
- BOD5
- Value:
- >= 3.6 - <= 12 mg O2/g test mat.
- Remarks on result:
- other: blank-corrected BOD
- Remarks:
- Test concentration : 100 mg/L Theoretical oxygen demand : 2.321 mg O2/mg
- Results with reference substance:
- Test concentration : 100 mg/L
Theoretical oxygen demand : 1.665 mg O2/mg
blank-corrected BOD after 28 days: 147.4 mg O2/L
degradation mean: 88% - Validity criteria fulfilled:
- yes
- Remarks:
- All validity criteria of the test method were met.
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- 2,2,4-Trimethyl-1-oxa-4-aza-2-silacyclohexane showed 3 % degradation after 28 day in a manometric respirometry test. Test item is considered to be “Not Readily Biodegradable“.
- Executive summary:
A study was performed to assess the ready biodegradability of 2,2,4-Trimethyl-1-oxa-4-aza-2-silacyclohexane in accordance with OECD Guideline 301 F.
A suspension of 2,2,4-Trimethyl-1-oxa-4-aza-2-silacyclohexane in a mineral medium was inoculated and incubated for 28 d under aerobic conditions. During this period, degradation was followed by continuous automated BOD determinations.
2,2,4-Trimethyl-1-oxa-4-aza-2-silacyclohexane showed:
1 % degradation after 7 days
1 % degradation after 14 days
2 % degradation after 21 days
3 % degradation after 28 days
2,2,4-Trimethyl-1-oxa-4-aza-2-silacyclohexane is considered to be “Not Readily Biodegradable“.
Reference
Description of key information
A study was performed to assess the ready biodegradability of 2,2,4-Trimethyl-1-oxa-4-aza-2-silacyclohexane in accordance with OECD Guideline 301 F.
A suspension of 2,2,4-Trimethyl-1-oxa-4-aza-2-silacyclohexane in a mineral medium was inoculated and incubated for 28 d under aerobic conditions. During this period, degradation was followed by continuous automated BOD determinations.
2,2,4-Trimethyl-1-oxa-4-aza-2-silacyclohexane showed 3 % degradation after 28 days.
2,2,4-Trimethyl-1-oxa-4-aza-2-silacyclohexane is considered to be “Not Readily Biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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