Registration Dossier

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1997 June
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1997
Report Date:
1997

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Version / remarks:
1992
Deviations:
no
GLP compliance:
yes (incl. certificate)

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
impurity
Type:
impurity
Test material form:
solid: bulk
Details on test material:
This composition is the usual techical grade of AlzChem AG. It will be used when test substance has this composition (or is very closed) or no specific information is available

Test solutions

Vehicle:
no

Test organisms

Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)
Details on test organisms:
Length: 2.0 +/- 1.0 cm

Study design

Test type:
static
Water media type:
freshwater
Remarks:
according to driking water prescription
Total exposure duration:
96 h

Test conditions

Test temperature:
22 °C
pH:
8.1
Dissolved oxygen:
>> 5 mg/mL (60 % of the saturation value at 22 °C)
Reference substance (positive control):
no
Remarks:
No reference substance was used due to animal protection affairs.

Results and discussion

Effect concentrationsopen allclose all
Duration:
96 h
Dose descriptor:
LC0
Effect conc.:
ca. 19 mg/L
Conc. based on:
other: TOC (total organic carbon)
Basis for effect:
mortality
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
>= 43 - <= 96 mg/L
Conc. based on:
other: TOC
Basis for effect:
mortality
Duration:
96 h
Dose descriptor:
LC100
Effect conc.:
ca. 96 mg/L
Conc. based on:
other: TOC
Basis for effect:
mortality

Any other information on results incl. tables

 

DL-6,8-Thioctic Acid concentrations

(obtained through conversion of the measured TOC-concentrations of the eluate)

LC0=

LC50=

LC100=

19 mg/L

range between 43 and 96 mg/L

96 mg/L

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
Lipoic acid has a LC50 range between 43 and 96 mg/L
Executive summary:

Lipoic acid has a LC50 range between 43 and 96 mg/L