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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference
Reference Type:
publication
Title:
Range-finding toxicity data: List IV
Author:
Smyth H. F. et al.
Year:
1951
Bibliographic source:
Archives of Industrial Hygiene and Occupational Medicine, Vol. 4(2), 119-122

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Butyl ethyl ether
EC Number:
211-055-7
EC Name:
Butyl ethyl ether
Cas Number:
628-81-9
Molecular formula:
C6H14O
IUPAC Name:
1-ethoxybutane

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
Statistics:
no data

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 870 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
In the study by Smyth et al., 1951 an oral LD50 of 1870 mg/kg bw was reported for rats after a single application of the test item.
Executive summary:

In the study by Smyth et al., 1951 an oral LD50 of 1870 mg/kg bw was reported for rats after a single application of butyl ethyl ether. The animals were observed for 14 days.