2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bisoxirane

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

not specified

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study was not conducted according to guideline/s and GLP but the report contains sufficient data for interpretation of study results

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1980

Materials and methods

Type of study / information:

cytogenic information

Endpoint addressed:

genetic toxicity

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Cytogenetic evaluation of peripheral lymphocytes of workers exposed to epoxy resins

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane

EC Number:

500-033-5

EC Name:

4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane

Cas Number:

25068-38-6

Molecular formula:

(C15 H16 O2 . C3 H5 Cl O)x

IUPAC Name:

4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane

Constituent 2

Reference substance name:

2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bisoxirane

EC Number:

216-823-5

EC Name:

2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bisoxirane

Cas Number:

1675-54-3

Molecular formula:

C21H24O4

IUPAC Name:

2,2'-[propane-2,2-diylbis(4,1-phenyleneoxymethylene)]dioxirane

Details on test material:

epoxy resins of the BADGE-type

Method

Details on study design:

Cytogenic evaluation was performed of peripheral lymphocytes from 18 workers currently exposed to epoxy resins of the BADGE-type. Nine workers were exposed to low molecular weights (<900), and 9 to higher molecular weight resins (average ~2000). Results were compared to an equal number of control individuals matched for sex and age.

Exposure assessment:

not specified

Details on exposure:

Nine workers were exposed to low molecular weights (<900), and 9 to higher molecular weight resins (average ~2000).

Results and discussion

Results:

There was no difference in chromosomal aberration frequency between the controls and the groups exposed to epoxy resin. The study gave no indication that exposure to epoxy resin produces visible damage to the chromosomes.

Any other information on results incl. tables

The present study did not give any indication that occupational exposure to low or high molecular epoxy resin produces visible chromosomal damage.

Applicant's summary and conclusion

Conclusions:

There was no difference in chromosomal aberration frequency between the controls and the groups exposed to epoxy resin.

Executive summary:

Cytogenetic evaluation was performed of peripheral lymphocytes from 18 workers currently exposed to epoxy resins of the type diglycidyl ether bisphenol-A (DGEBA). 9 workers were exposed to low molecular (average MW <900) and 9 to high molecular (average MW about 2000) epoxy resins. The results were compared with an equal number of control individuals matched for sex and age. There was no difference in chromosomal aberration frequency between the controls and the groups exposed to epoxy resin. Thus, this study gave no indication that exposure to epoxy resin produces visible damage to the chromosomes.