Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 216-823-5 | CAS number: 1675-54-3
Carcinogenicity
Administrative data
Description of key information
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 15 mg/kg bw/day
Carcinogenicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 1 mg/kg bw/day
Justification for classification or non-classification
Additional information
A number of chronic toxicity/carcinogenicity studies have been conducted. In the most recently conducted studies, the NOAEL was 15 and 100 mg/kg/day in male and female rats, respectively, following two years oral administration of BADGE. Decreased body weight and an enlarged cecum were observed in male rats at 15 mg/kg/day in the oral study. In the dermal chronic toxicity/carcinogenicity studies, male mice and female rats were used. The systemic NOEL was 1 mg/kg/day in female rats and 100 mg/kg/day in male mice. Histopathologic changes were observed in the liver of female rats administered 10 and 100 mg/kg/day. These changes were attributed to ingestion since the test material was not occluded. In male mice the NOEL at the application site was 0.1 mg/kg/day. Epidermal hyperplasia, chronic dermal inflammation and epidermal crusts were observed histopathologically at dosages of 10 and 100 mg/kg/application in male mice.
Carcinogenicity: via oral route (target organ): digestive: cecum
Carcinogenicity: via dermal route (target organ): digestive: liver
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
