2,2'-[ethylenebis(oxy)]bisacetic acid

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 2017-04-18 to 2017-05-16

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

yes

Remarks:

refer to 'Principles of method if other than guideline'

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

yes

Remarks:

refer to 'Principles of method if other than guideline'

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7840 (Water Solubility)

Deviations:

yes

Remarks:

refer to 'Principles of method if other than guideline'

Principles of method if other than guideline:

As the water solubility of the test item determined in a preliminary test showed that the test item is very soluble, as a main test the Preliminary test (OECD 105) with visual detection at room temperature was performed.

GLP compliance:

yes (incl. QA statement)

Type of method:

other: preliminary test (OECD 105), visual detection

Specific details on test material used for the study:

Batch No.: 0458507022_R_JM
Purity: 99.8 %

Key result

Water solubility:

> 835 g/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

0.5

Table 1. Water solubility test

Experiment 1		Experiment 2
x (g) Test Item added to 5 mL water	Observation	x (g) Test Item added to 5 mL water	Observation
5.0389	clear liquid phase	5.0968	clear liquid phase
6.0944	clear liquid phase	6.1011	clear liquid phase
7.1130	clear liquid phase	7.1083	clear liquid phase
8.1360	clear liquid phase	8.1107	clear liquid phase
9.2156	clear liquid phase	9.1332	clear liquid phase
10.2277	clear liquid phase	10.1399	clear liquid phase
11.2592	precipitation of test item	11.1724	precipitation of test item

The pH value of the clear liquid phase at the ca. 835 g/L (10.0277 g and 10.0091 g test item / 12 mL[ses1] ) concentration level was determined to be: 0.5.

Conclusions:

The water solubility of the test item was determined to be > 835 g/L (ca. 10 g / 12 mL) at room temperature based on the Preliminary Test (OECD 105).

Executive summary:

The water solubility was determined according to OECD 105, Regulation (EC) No. 440/2008 method A.6 and OPPTS 830.7840. In a preliminary test no saturated solution of the test item could not be prepared, therefore, the standard methods for determination of the water solubility are not feasible. Therefore, the water solubility of the test item was determined using the Preliminary test (OECD 105) with visual detection. 5 - 11 g test item were added to 5 mL water in 1 g steps. After each addition of an amount of test item, the mixture was shaken and was visually checked for any undissolved parts of the sample. The pH of each sample was recorded. The water solubility of the test substance was determined to be > 835 g/L (ca. 10 g / 12 mL) at room temperature based on the Preliminary Test (OECD 105) (pH 0.5).

Description of key information

The water solubility of the test item was determined to be > 835 g/L (ca. 10 g / 12 mL) at room temperature based on the Preliminary Test (OECD 105).

Additional information

The water solubility was determined according to OECD 105, Regulation (EC) No. 440/2008 method A.6 and OPPTS 830.7840. In a preliminary test no saturated solution of the test item could not be prepared, therefore, the standard methods for determination of the water solubility are not feasible. Therefore, the water solubility of the test item was determined using the Preliminary test (OECD 105) with visual detection. 5 - 11 g test item were added to 5 mL water in 1 g steps. After each addition of an amount of test item, the mixture was shaken and was visually checked for any undissolved parts of the sample. The pH of each sample was recorded. The water solubility of the test substance was determined to be > 835 g/L (ca. 10 g / 12 mL) at room temperature based on the Preliminary Test (OECD 105) (pH 0.5).