4'-trans-Butyl-[1,1'-bicyclohexyl]-4-on

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

04.12.91 - 23.05.92

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

GLP compliance:

no

Type of method:

column elution method

Key result

Water solubility:

0 mg/L

Conc. based on:

test mat.

Temp.:

25 °C

pH:

7

Preliminary test

Three preliminary tests were carried out with specified amounts of the test item and 10 mL demineralized water, respectively. After each addition of the amount of water, the mixture was stirred for 16 hours, and visually checked for any undissolved particles. The particles were centrifuged and the concentration of the test item in the solution was determined via gas chromatography.

 

Temperature	Undissolved particles	Concentration/mg/mL
15 °C	Yes	0.00002
20 °C	Yes	0.00001
25 °C	Yes	0.00002

 

Mean: 0.000016

The water solubility was not temperature dependent.

 

Column elution method

0.13 mg of the test item were dissolved in 100 mL in methylene dichloride and added to 20 g of silica gel. The solvent was then removed under reduced pressure using a rotary evaporator (40 °C, approx. 20 mbar) and dried in the vacuum at 30 °C. The dry residues were placed into the columns of the test apparatus, which have afterwards been filled with water (test temperature: 20 °C). After a swelling time of 2 h pumps were started to rinse the test item coated silica gel with demineralized water. After 15 hours, the pumps were stopped and a sample of 5 ml was taken. The concentration of the test item was quantified by gas chromatography.

 

Table column elution method, column 1 (approx. 25 mL/h)

sample no	V / mL	pH	Water solubility / mg/L
1	5	7.8	< 0.0001
2	5	7.8	< 0.0001
3	5	7.7	< 0.0001
4	5	7.7	< 0.0001
5	5	7.8	< 0.0001
6	5	7.7	< 0.0001

 

The water solubility was found to be < 0.0001 mg/L.

Conclusions:

The water solubility cs of the test item at a temperature of 20°C was determined according to the column elution method. It was found to be below the quantification limit: cs < 0.0001 mg/L.

Executive summary:

The water solubility was determined according to A.6 using the column elution method. The preliminary test showed that the water solubility of the test item is < 10 mg/L. The column elution method showed a solubility: cs < 0.0001 mg/L.

Description of key information

The water solubility cs of the test item at a temperature of 20°C was determined according to the column elution method. lt was found to be cs < 0.0001 mg/L

Additional information

The water solubility was determined according to EU A.6 using the column elution method. The preliminary test showed that the water solubility of the test item is < 10 mg/L. The column elution method showed a solubility of cs < 0.0001 mg/L