Registration Dossier
Registration Dossier
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EC number: 201-063-9 | CAS number: 77-85-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable and sufficiently documented
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- 2 animals, dose 50 mg/animal into the conjunctival sac, post exposure period 7 days.
- GLP compliance:
- no
Test material
- Reference substance name:
- Propylidynetrimethanol
- EC Number:
- 201-074-9
- EC Name:
- Propylidynetrimethanol
- Cas Number:
- 77-99-6
- Molecular formula:
- C6H14O3
- IUPAC Name:
- 2-ethyl-2-(hydroxymethyl)propane-1,3-diol
- Details on test material:
- No data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- no data
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the other eye of each of the 2 rabbits
- Amount / concentration applied:
- amount: 50 mg
- Duration of treatment / exposure:
- 7 days
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- no data
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 0 h
- Score:
- >= 0 - 1
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1, 2 and 7 d
- Score:
- 0
- Reversibility:
- other: score = 0 at any time point
- Other effects:
- no data
Any other information on results incl. tables
No data
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
A dose of 50 mg/animal was applied into the conjunctival sac of one eye of each of 2 rabbits, postexposure observation period 7 days. Trimethylolpropane is not irritating (Bayer AG 1979).
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