2-sec-butylcyclohexan-1-one

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1978

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1978

Report date:

1978

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Rats were dosed at 1.22, 1.95, 3.12, 5 g/Kg

GLP compliance:

no

Remarks:

Test performed prior to the GLP guideline

Test type:

fixed dose procedure

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-sec-butylcyclohexan-1-one

EC Number:

238-830-2

EC Name:

2-sec-butylcyclohexan-1-one

Cas Number:

14765-30-1

Molecular formula:

C10H18O

IUPAC Name:

2-(butan-2-yl)cyclohexan-1-one

Specific details on test material used for the study:

Sample marking: 77-182, Freskomenthe

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

not specified

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

not specified

Details on oral exposure:

not specified

Doses:

1.22 mg/kg
1.95 mg/kg
3.12 mg/kg
5.00 mg/kg

No. of animals per sex per dose:

10 males per group (per dose)

Control animals:

no

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

2 400 mg/kg bw

Based on:

test mat.

95% CL:

ca. 1 900 - ca. 3 000

Remarks on result:

other: 95% confidence limits

Mortality:

1220 mg/kg - 0/10 animals died.
195 mg/kg - 4/10 animals died.
3120 mg/kg - 8/10 animals died.
5000 mg/kg - 10/10 animals died.

Clinical signs:

other: All doses: lethargy, ataxia, coma, ptosis, piloerection, diarrhea (see details in "Any other information on results" field below)

Gross pathology:

not specified

Other findings:

not specified

Any other information on results incl. tables

Dose: 1.22 g/kg; clinical signs:

 Clinical signs observed included lethargy, ataxia, coma, ptosis, chromorhinorrhea, piloerection, diarrhea and chromodacryorrhea. Necropsy revealed 9/10 animals were normal; red exudate in the nose/mouth in 1/10 animals.

Dose: 3.12 g/kg clinical signs; lethal

8/10 deaths; Deaths occurred on days 1 and 2. Clinical signs observed included coma, prostration, ataxia, chromorhinorrhea, chromodacryorrhea, lethargy, diarrhea and emaciation. Necropsy revealed 2/10 animals were normal; red exudate in the nose/mouth in 8/10 animals; brown anogenital exudate in 3/10 animals; red areas in the intestines in 8/10 animals; yellow areas in the intestines in 8/10 animals; gelatinous intestines in 3/10 animals; bloated intestines in 5/10 animals; yellow fluid in the intestines in 3/10 animals; red areas in the stomach in 5/10 animals; mottled liver in 8/10 animals; dark areas in the lungs in 8/10 animals; mottled kidney in 7/10 animals; white nodule on the outer surface of the kidney in 1/10 animals; dark spleen in 3/10 animals; mottled spleen in 5/10 animals; creamy yellow fluid in stomach in 2/10 animals.

Dose: 1.95 g/kg clinical signs; lethal

4/10 deaths; Deaths occurred on days 2 and 12. Clinical signs observed included coma, prostration, ataxia, chromorhinorrhea, diarrhea, chromodacryorrhea, ptosis and emaciation. Necropsy revealed 3/10 animals were normal; 1/10 animals cannibalized; red exudate in the nose/mouth in 3/10 animals; yellow exudate in the nose/mouth in 2/10 animals; brown anogenital exudate in 3/10 animals; red areas in the intestines in 3/10 animals; yellow areas in the intestines in 3/10 animals; gelatinous intestines in 3/10 animals; orange fluid in the stomach in 2/10 animals; yellow fluid in the stomach in 1/10 animals; mottled liver in 3/10 animals; dark lungs in 3/10 animals; dark kidney in 4/10 animals; mottled kidney in 1/10 animals; mottled spleen in 3/10 animals; bladder-blood contained in urine in 1/10 animals.

Dose: 5 g/kg clinical signs; lethal

10/10 deaths. Deaths occurred on days 1 and 2. Clinical signs observed included coma, ataxia, lethargy, ptosis and chromorhinorrhea. Necropsy revealed red exudate in the nose/mouth in 2/10 animals; brown anogenital exudate in 1/10 animals; red areas in the intestines in 5/10 animals; yellow areas in the intestines in 10/10 animals; bloated intestines in 7/10 animals; red areas in the stomach in 9/10 animals; stomach, area approximately 10% bubbled out and thin in 4/10 animals; dark liver in 1/10 animals; mottled liver in 8/10 animals; dark liver in 3/10 animals; dark areas in the lungs in 7/10 animals; mottled kidney in 5/10 animals; pale kidney in 2/10 animals; mottled spleen in 5/10 animals; creamy yellow fluid in the stomach in 7/10 animals.

Applicant's summary and conclusion

Interpretation of results:

Category 5 based on GHS criteria

Conclusions:

In conclusion the LD50 has been detrmined to be LD50(rat)= 2400 mg/kg bw (1900-3000 mg/kg bw).
Freskomenthe meets the criteria to be classified Category 5 according to the GHS classification.

Executive summary:

LD50 has been detrmined to be LD50(rat)= 2400 mg/kg bw (1900-3000 mg/kg bw).

Freskomenthe meets the criteria to be classified Category 5  according to the GHS classification.