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EC number: 283-130-2
CAS number: 84540-37-4
To test for primary skin
irritation, 0.5g of the test material was mixed with some drops of
liquid paraffin to ensure good contact to the skin. Afterwards, the test
material was spread onto 4 cm2 patches and applied to the intact skin of
previously shaven rabbits for a 4 hours period under occlusive
The first examination of the
treated skin sites followed 1 hour after removal of the patches. Then
examinations were performed daily for further 7 days.
Under the given experimental conditions erythema (score 1) in the
treated areas were observed in two of the three animals from day 1 until
3 of the study.
The cumulative mean scores for erythema were:
Day 1: 0.0 (1 hour)
Day 2: 0.7 (24 hours)
Day 3: 0.7 (48 hours)
Day 4: 0.0 (72 hours)
Edema have not been observed.
The control sites, treated with liquid paraffin, showed no signs of
According to the results of the
study, for regulatory purposes there is no need for classification (all
mean scores are below 2,3).
This study was performed according to GLP and methods applied are fully
compliant with OECD TG 404.
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