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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
Single dose
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data from review of lithium carbonate published by US National Institute for Occupational Safety and Health (NIOSH) and listed in RTECSThree acute studies are cited in the review and the lowest figure is used for classification. The results below cover the reported range

Data source

Reference
Reference Type:
review article or handbook
Title:
Registry of Toxic Effects of Chemical Substances (RTECS)
Author:
Published by NIOSH
Year:
2016
Bibliographic source:
National Institute for Occupational Safety and Health (NIOSH)

Materials and methods

Test guideline
Qualifier:
no guideline available
Version / remarks:
No details provided in review document
Principles of method if other than guideline:
Acute toxicity in rat is reported in terms of LD50
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Lithium carbonate
EC Number:
209-062-5
EC Name:
Lithium carbonate
Cas Number:
554-13-2
Molecular formula:
CH2O3.2Li
IUPAC Name:
dilithium carbonate
Specific details on test material used for the study:
No specific detailsLithium carbonate is considered to be a more reliable source of lithium for assessing lithium toxicity as it is less irritant than lithium chloride and will not cause mortality due to local damage.

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
Details are not provided in the review document
Doses:
Not specificed
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 552 - < 770 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

Data from review of lithium carbonate published by US National Institute for Occupational Safety and Health (NIOSH) and listed in RTECS

Three acute studies are cited in the review and the range is reported above.

The review does not include clinical signs, but other sources suggest effects to kidneys; this is similar to th etoxic effects of sodium.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
The results do not impact on the classification and are provided as an indicator of the possible toxicity of lithium. It should be noted that the NOAEL for lithium carbonate in repeated studies is not a lot lower than the LD50 and several publications note a sharp borderline between tolerated levels and toxic levels.