Ethyl diphenylcarbamate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

March 6, 2017 - March 15, 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Key result

Water solubility:

ca. 0.026 g/L

Conc. based on:

test mat.

Incubation duration:

>= 1 - <= 3 d

Temp.:

20 °C

pH:

>= 6.46 - <= 6.6

In the test, the following flasks were used:

Flasks 1 (samples 1 & 2) – for one day at 30ºC;

Flasks 2 (samples 3 & 4) – for two days at 30ºC;

Flask 3 (samples 5 & 6) – for three days at 30ºC.

The individual results from each of three flasks, which should not differ by more than 15%, are averaged. If the concentrations measured in at least the two last samples do not differ by more than 15% the test is satisfactory.

Water solubility is expressed in mass of solute per volume of solution.

Table 1. Results of the preliminary test

0.1g in x mL of solution	0.1	0.5	1	2	10	100	1000	> 1000
Soluble (+/-)	-	-	-	-	-	-	-	+
Approximate solubility, g/L	> 1000	1000 to 200	200 to 100	100 to 50	50 to 10	10 to 1	1 to 0.1	<0.1

Table 2: Study solution in water

Sample day/ flask		Weight of the sample [mg]	Dilution [mL]	Cp [mg/mL]	Peak area		Average peak area Ap	X [g/kg]
1	1	991.85	10	101.32	293255	293122	293188.5	0.0257
	2	995.70		101.05	292957	293585	293271	0.0258
2	3	1014.55	10	100.90	290141	291210	290675.5	0.0256
	4	1010.05		100.33	296074	295871	295972.5	0.0262
3	5	1008.95	10	100.75	292148	292891	292519.5	0.0258
	6	1003.00		100.57	295399	293677	294538	0.0260

 

 Table 3. Results of test item solubility

in water

Mixing timeat 30 ºC [days, flasks]	1		2		3
Samples	1	2	3	4	5	6
Temperature, ºC	19.8		19.8		20.0
pH	6.46		6.53		6.60
Concentration ofEthyl diphenylcarbamate, g/kg	0.0257	0.0258	0.0256	0.0262	0.0258	0.0260
Average concentration ofEthyl diphenylcarbamate,g/kg	0.0258		0.0259		0.0259
Average concentrationEthyl diphenylcarbamate, g/kg	0.0259

Conclusions:

The solubility of the test iem at 20 ± 0.5 ºC and at pH ranging from 6.46 to 6.60 is 0.0259 g/L.

Executive summary:

The study of the determination of test item solubility in water at one pH value using shake flask method was performed according to OECD 106 and EU method A.6, following GLP. The test item content in obtained samples for study of the solubility in the water at three pH values was determined by HPLC method, using a liquid chromatograph Spectra-Physics. The solubility of the test iem at 20 ± 0.5 ºC and at pH ranging from 6.46 to 6.60 is 0.0259 g/L.

Description of key information

Key study: OECD 106 and EU method A.6. GLP study. The solubility of the test iem at 20± 0.5 ºC and at pH ranging from 6.46 to 6.60 is 0.0259 g/L.

Key value for chemical safety assessment

Water solubility:

0.026 g/L

at the temperature of:

20 °C

Additional information

Key study: The study of the determination of test item solubility in water at one pH value using shake flask method was performed according to OECD 106 and EU method A.6, following GLP. The test item content in obtained samples for study of the solubility in the water at three pH values was determined by HPLC method, using a liquid chromatograph Spectra-Physics. The solubility of the test iem at 20± 0.5 ºC and at pH ranging from 6.46 to 6.60 is 0.0259 g/L.