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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
March 1, 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: Knudsen cell
Key result
Temp.:
ca. 20 °C
Vapour pressure:
ca. 1.27 Pa
Key result
Temp.:
ca. 25 °C
Vapour pressure:
ca. 2.49 Pa

Table No.1: Results of vapour pressure

Temperature ºC

 

Vapour pressure (Pa)

 

Evaporation rate (ug/min)

 

28.4

3.85

41.35

32.5

6.68

71.30

36.7

11.20

118.64

40.9

18.31

192.74

Vapour pressure of test item at 20ºCand 25ºC was calculated on the basis of equation log (p) = f (1/t) = a-b/(t+273.15) where:

p – vapour pressure in Pa,

t – temperature inºC,

a- 17.5835

b- 5124.17

R2- 0.9948

obtained for four measurement points: 28.4 32.5, 36.7 and 40.9ºC.

Conclusions:
The vapour pressure of the tested item is 1.27 Pa (20ºC) and 2.49 Pa (25ºC).
Executive summary:

In accordance with OECD 104 (EEC A4) and GLP study, the vapour pressure was determinated using Effusion method: Knudsen cell possessing 0,1 mm orifice diameter. Vapour pressure was determinated by estimation of the masse of tested substance flowing out per unit of time of a Knudsen cell in the form of vapour, through a micro-orifice of 0.1 mm diameter, under ultravacuum conditions.The vapour pressure of the tested item is 1.27 Pa (20ºC) and 2.49 Pa (25ºC).

Description of key information

Key study: OECD guideline 104 and GLP study. The vapour pressure of the tested item is 1.27 Pa at 20ºC and 2.49 Pa at 25ºC.

Key value for chemical safety assessment

Vapour pressure:
1.27 Pa
at the temperature of:
20 °C

Additional information

Key study: In accordance with OECD 104 (EEC A4) and GLP study, the vapour pressure was determined. Effusion method: Knudsen cell was applied. The vapour pressure of the tested item is 1.27 Pa (20ºC) and 2.49 Pa (25ºC).

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