Registration Dossier

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
08 April 2008
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affcet the quality of relevant results.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2008

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Remarks:
Date of inspection: 21/08/07 Date of signature: 15/10/07
Type of method:
effusion method: vapour pressure balance

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
Sponsor's identification : VCBK3810
Description : black powder
Batch number : N006746
Date received : 25 February 2008
Storage conditions : room temperature in the dark

Results and discussion

Vapour pressure
Temp.:
25 °C
Vapour pressure:
0 Pa

Any other information on results incl. tables

 Results:

Run1

Temperature (ºC)

Temperature (K)

Reciprocal Temperature (K-1)

Mass Difference (µg)

Mass Difference (kg)

Vapour Pressure (Pa)

Log10Vp

185

458.15

0.002182691

6.43

6.430E-09

0.008926487

-2.049319406

186

459.15

0.002177937

6.43

6.430E-09

0.008926487

-2.049319406

187

460.15

0.002173204

5.86

5.860E-09

0.008135181

-2.089632763

188

461.15

0.002168492

7.24

7.240E-09

0.010050975

-1.997791813

189

462.15

0.002163800

7.08

7.080E-09

0.009828854

-2.007497121

190

463.15

0.002159128

7.16

7.160E-09

0.009939914

-2.002617356

191

464.15

0.002154476

9.36

9.360E-09

0.012994078

-1.886254530

192

465.15

0.002149844

8.38

8.380E-09

0.011633587

-1.934286360

193

466.15

0.002145232

11.07

1.107E-08

0.015367996

-1.813382758

194

467.15

0.002140640

12.69

1.269E-08

0.017616971

-1.754068757

195

468.15

0.002136067

12.53

1.253E-08

0.017394850

-1.759579308

No statistical analysis is given due to the nature of the plot

Run 2

Temperature (ºC)

Temperature (K)

Reciprocal Temperature (K-1)

Mass Difference (µg)

Mass Difference (kg)

Vapour Pressure (Pa)

Log10Vp

185

458.15

0.002182691

6.02

6.020E-09

0.008357302

-2.077933887

186

459.15

0.002177937

6.51

6.510E-09

0.009037548

-2.043949390

187

460.15

0.002173204

6.02

6.020E-09

0.008357302

-2.077933887

188

461.15

0.002168492

5.78

5.780E-09

0.008024121

-2.095602540

189

462.15

0.002163800

6.83

6.830E-09

0.009481790

-2.023109675

190

463.15

0.002159128

9.28

9.280E-09

0.012883018

-1.889982403

191

464.15

0.002154476

7.49

7.490E-09

0.010398039

-1.983048561

192

465.15

0.002149844

9.19

9.190E-09

0.012758074

-1.894214867

193

466.15

0.002145232

9.03

9.030E-09

0.012535953

-1.901842628

194

467.15

0.002140640

9.11

9.110E-09

0.012647014

-1.898012002

195

468.15

0.002136067

11.88

1.188E-08

0.016492484

-1.782713938

No statistical analysis is given due to the nature of the plot

Run 3:

Temperature (ºC)

Temperature (K)

Reciprocal Temperature (K-1)

Mass Difference (µg)

Mass Difference (kg)

Vapour Pressure (Pa)

Log10Vp

185

458.15

0.002182691

5.78

5.780E-09

0.008024121

-2.095602540

186

459.15

0.002177937

6.51

6.510E-09

0.009037548

-2.043949390

187

460.15

0.002173204

5.53

5.530E-09

0.007677057

-2.114805247

188

461.15

0.002168492

5.78

5.780E-09

0.008024121

-2.095602540

189

462.15

0.002163800

7.73

7.730E-09

0.010731220

-1.969350885

190

463.15

0.002159128

7.24

7.240E-09

0.010050975

-1.997791813

191

464.15

0.002154476

7.57

7.570E-09

0.010509099

-1.978434499

192

465.15

0.002149844

8.87

8.870E-09

0.012313832

-1.909606759

193

466.15

0.002145232

10.98

1.098E-08

0.015243053

-1.816928039

194

467.15

0.002140640

9.03

9.030E-09

0.012535953

-1.901842628

195

468.15

0.002136067

11.07

1.107E-08

0.015367996

-1.813382758

No statistical analysis is given due to the nature of the plot.

 Discussion:

No statistical analyses were performed because the balance readings were too low and variable for a line of best fit to have any meaning. Instead it was considered more appropriate to impose a regression slope on a chosen data point to provide an estimate of the maximum value for the vapour pressure at 25 ºC.

Run 3 was chosen because the sample had been under vacuum for the longest period prior to this run and so degassing would have been the most complete. The reading at 193 ºC (466.15 K) was chosen because this is the data point which gives the highest estimated vapour pressure at any given temperature when a slope of –1500 K is imposed upon it.

The value of –1500 K is an in-house value and is the shallowest slope observed whilst determining the vapour pressure on a wide range of samples using the vapour pressure balance method. Extrapolation to 25ºC gave a vapour pressure of 2.344 x 10 -4 Pa which has been taken as a maximum for this material.

The test material did not change in appearance under the conditions used in the determination.

Applicant's summary and conclusion

Conclusions:
The vapour pressure of the test material has been determined to be less than 2.4 x 10E-4 Pa at 25ºC. The vapour pressure balance method was used based on a low vapour pressure.
Executive summary:

The vapour pressure was determined using a vapour pressure balance with measurements being made at several temperatures and linear regression analysis used to calculate the vapour pressure at 25°C. Testing was conducted using Method A4 of Commission Directive 92/69/EEC (which constitutes Annex V of Council Directive 67/548/EEC). The vapour pressure of the test material has been determined to be less than 2.4 x 10-4 Pa at 25ºC.