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EC number: 610-337-0
CAS number: 473257-15-7
Read Across: LD50 > 2000 mg/kg bw
The test material was tested for
acute toxicity in rats after single oral administration of 2000 mg/kg
body weight. Directly before administration the test material was
prepared with aqueous Methocel K4M Premium solution as the vehicle. The
study was performed according to the OECD Guideline for Testing of
Chemicals, No. 401.
signs of intoxication occurred after treatment.
weight development of the treated rats was normal.
the rats survived the observation period.
necropsy two rats showed either focal or diffuse grey-red discoloration
of the thymus. In all other rats no organ alterations were seen.
regulatory purposes, the median lethal dose (LD50),
after an observation period of 15 days can be declared as >
This study was performed according
to GLP and is fully compliant OECD TG 401. Based on the result of this
study, it is concluded that the test material has no acute toxic
potential and that the LD50 value is higher than 2000 mg/kg
after single oral administration in rats.
For this endpoint information from a structural similar compound,
is available. This study for this similar compound was performed
according to GLP and the methods applied are fully compliant with OECD
TG 423. See chapter 13 report for a more detailed justification.
For this endpoint information from a structural similar compound is
available. This study for this similar compound was performed according
to GLP and the methods applied are fully compliant with OECD TG 423. See
chapter 13 report for a more detailed justification.
Based on the provided information there is no need to classified
according to the EU Regulation (EC) No 1272/2008 on
Classification,Labelling and Packaging of Substances and Mixtures.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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