Reaction mass of 7539-04-0 and pentaerythritol tetrakis(3-mercaptopropionate) and 2-{3-(3-mercaptopropionyl)thiopropionyl}oxymethyl-2-(3-mercaptopropionyl)oxymethyl-1,3-propanediyl bis(3-mercaptopropionate)

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics, other

Type of information:

other: Theoretical assessment

Adequacy of study:

key study

Study period:

2016

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Theoretical assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2016

Materials and methods

Test material

Test material information

Constituent 1

Reference substance name:

Reaction mass of 7539-04-0 and pentaerythritol tetrakis(3-mercaptopropionate) and 2-{3-(3-mercaptopropionyl)thiopropionyl}oxymethyl-2-(3-mercaptopropionyl)oxymethyl-1,3-propanediyl bis(3-mercaptopropionate)

Molecular formula:

not applicable (generic description of the multi-constituent)

IUPAC Name:

Reaction mass of 7539-04-0 and pentaerythritol tetrakis(3-mercaptopropionate) and 2-{3-(3-mercaptopropionyl)thiopropionyl}oxymethyl-2-(3-mercaptopropionyl)oxymethyl-1,3-propanediyl bis(3-mercaptopropionate)

Test material form:

other: Liquid

Details on test material:

- Name of test material (as cited in study report): PEMP product
- Appearance: Colourless transparant liquid

Specific details on test material used for the study:

Theoretical assessment: no test substance was used.

Results and discussion

Main ADME results

Type:

absorption

Results:

For risk assessment purposes, oral and dermal absorption of PEMP product is set at 50%, adsorption via inhalation is set at 100%.

Applicant's summary and conclusion

Conclusions:

Based on all information available, for risk assessment purposes oral and dermal absorption of PEMP product is set at 50%, adsorption via inhalation is set at 100%.