Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-420-7 | CAS number: 120-72-9
Endpoint summary
Administrative data
Description of key information
Adsorption / desorption
Adsorption study was conducted for determining the soil adsorption coefficient (Koc) of test chemical on synthetic soil composed of sand, clay (montmorillonite) coated with various amounts of humic acid (from peer reviewed journal (M. Rebhun et. al.; 1992) and authoritative databases). Synthetic soil containing 88-90% of sand, 10% of clay, 0-2% of humic acid was used as a soil during the study. Study was performed using the recirculating isotherm method in which 1—2 g of the sobent were loaded into the 8 X 1 cm glass column over a piece of glass wool. The column was connected to a 250 ml reservoir containing a buffered (0.05 M phosphate) solution of the organic absorbant in a precalculated concentration. The reservoir was sealed with a Teflon stopper containing a thin needle for generating a downstream of air at atmospheric pressure for reducing the losses due to chemical voltalization. After each run, concentration was measured, and the solution was recycled again through the column. An equilibrium concentration was determined hen no change in concentration was observed after two sequentials runs. All experiments were performed using the demineralized and carbon purified water at a temperature of 20±2°C and final pH was 5.0-6.0. The concentration of test chemical was determined by HPLC, on a reverse phase column of 10µm Bondapak C11 250 X 4 mm, and a U. V. vis detector seat at 250 nm. A linear gradient of 20-100% methanol-water (2% per min) was used for separation. The concentrations were calculated from a calibration curve obtained with known concentrations of authentic samples of the same compounds. Linear adsorption isotherm was obtained for solute and adsorbents in the concentration range used in the study. The slope of linear adsorption isotherms represent adsorption coefficient (Km) of the test chemical on pure mineral and was determined to be 1.65 ml/g for 10% clay. The adsorption coefficient (Koc) value of test chemical was determined to be 187 (logKoc = 2.271). This Koc value indicates that the test chemical hasa low sorption tosoil and sediment and therefore have moderate migration potential to ground water.
Additional information
Adsorption / desorption
Various experimental studies of the target chemical were reviewed for the adsorption end point which are summarized as below:
In an experimental study from peer reviewed journal (M. Rebhun et. al.; 1992) and authoritative databases,adsorption study was conducted for determining the soil adsorption coefficient (Koc) of test chemical on synthetic soil composed of sand, clay (montmorillonite) coated with various amounts of humic acid. Synthetic soil containing 88-90% of sand, 10% of clay, 0-2% of humic acid was used as a soil during the study. Study was performed using the recirculating isotherm method in which 1—2 g of the sobent were loaded into the 8 X 1 cm glass column over a piece of glass wool. The column was connected to a 250 ml reservoir containing a buffered (0.05 M phosphate) solution of the organic absorbant in a precalculated concentration. The reservoir was sealed with a Teflon stopper containing a thin needle for generating a downstream of air at atmospheric pressure for reducing the losses due to chemical voltalization. After each run, concentration was measured, and the solution was recycled again through the column. An equilibrium concentration was determined hen no change in concentration was observed after two sequentials runs. All experiments were performed using the demineralized and carbon purified water at a temperature of 20±2°C and final pH was 5.0-6.0. The concentration of test chemical was determined by HPLC, on a reverse phase column of 10µm Bondapak C11 250 X 4 mm, and a U. V. vis detector seat at 250 nm. A linear gradient of 20-100% methanol-water (2% per min) was used for separation. The concentrations were calculated from a calibration curve obtained with known concentrations of authentic samples of the same compounds. Linear adsorption isotherm was obtained for solute and adsorbents in the concentration range used in the study. The slope of linear adsorption isotherms represent adsorption coefficient (Km) of the test chemical on pure mineral and was determined to be 1.65 ml/g for 10% clay. The adsorption coefficient (Koc) value of test chemical was determined to be 187 (logKoc = 2.271). This Koc value indicates that the test chemical has a low sorption to soil and sediment and therefore have moderate migration potential to ground water.
Another adsorption study was conducted for determining the adsorption coefficient (Koc) value of test chemical (Handbook, 2007). The adsorption coefficient (Koc) value of test chemical was determined to be 48.977 (logKoc = 1.69). This Koc value indicates that the test chemical has a low sorption to soil and sediment and therefore have moderate migration potential to ground water.
In a supporting study from authoritative databases (2019), adsorption study was conducted for estimating the adsorption coefficient (Koc) value of test chemical. The adsorption coefficient (Koc) value was calculated using a logKow of 2.14 and a regression derived equation. The adsorption coefficient (Koc) value of test chemical was estimated to be 350 (Log Koc = 2.54). This Koc value indicates that the test chemical has a moderate sorption to soil and sediment and therefore have slow migration potential to ground water.
For the test chemical, KOCWIN model of Estimation Programs Interface was used to predict the soil adsorption coefficient i.e Koc value of test chemical. The soil adsorption coefficient i.e Koc value of test chemical was estimated to be 847.4 L/kg (log Koc=2.92) by means of MCI method (at 25 deg C). This Koc value indicates that the test chemical has a moderate sorption to soil and sediment and therefore have slow migration potential to ground water.
On the basis of above results for test chemical, it can be concluded that the logKoc value of test chemical was evaluated to be ranges from 1.69 to 2.92, respectively indicating that the test chemical has a low to moderate sorption to soil and sediment and therefore have moderate to slow migration potential to ground water.
In addition to this, adsorption endpoint can also be considered for waiver as per in accordance with column 2 of Annex VIII of the REACH regulation, testing for this end pointis scientifically not necessary and does not need to be conducted because the substance has a low octanol water partition coefficient and the adsorption potential of the substance is related to this parameter.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
