Indole

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

(Q)SAR

Adequacy of study:

key study

Study period:

2017

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

QSAR

Principles of method if other than guideline:

QSAR: Acute aquatic toxicity on fish of the target chemical was estimated by using three predictors: ACD/Percepta, ECOSAR and Vega. The three predictors were employed in order to assess and combine the predictions and thus enhance the reliability of the final prediction. In the combined assessment only reliable predictions are to be taken into account.

GLP compliance:

no

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

ca. 19.76 mg/L

Nominal / measured:

not specified

Conc. based on:

not specified

Remarks:

QSAR

Basis for effect:

not specified

Remarks:

QSAR

Validity criteria fulfilled:

no

Conclusions:

Acute aquatic toxicity on fish of the target chemical was estimated by using three predictors: ACD/Percepta, ECOSAR and Vega. The three predictors were employed in order to assess and combine the predictions and thus enhance the reliability of the final prediction. In the combined assessment only reliable predictions are to be taken into account.
In the case of the target Indole, the three predictors provided reliable predictions of different level of reliability (moderate ACD/Percepta, borderline ECOSAR, and high Vega). In particular, ACD/Percepta provided a moderately reliable LC50 prediction equal to 20 mg/L, ECOSAR provided a borderline reliable LC50 equal to 2.34 mg/L and Vega provided a highly reliable LC50 equal to 19.76 mg/L. The in silico assessment of acute aquatic toxicity on Daphnia for the target Indole was based on Vega prediction, which provided the most reliable 96h-LC50 prediction equal to 19.76 mg/L (Pimephales promelas). The prediction was assessed as high reliable.

Executive summary:

Acute aquatic toxicity on fish of the target chemical was estimated by using three predictors: ACD/Percepta, ECOSAR and Vega. The three predictors were employed in order to assess and combine the predictions and thus enhance the reliability of the final prediction. In the combined assessment only reliable predictions are to be taken into account.

In the case of the target Indole, the three predictors provided reliable predictions of different level of reliability (moderate ACD/Percepta, borderline ECOSAR, and high Vega). In particular, ACD/Percepta provided a moderately reliable LC50 prediction equal to 20 mg/L, ECOSAR provided a borderline reliable LC50 equal to 2.34 mg/L and Vega provided a highly reliable LC50 equal to 19.76 mg/L. The in silico assessment of acute aquatic toxicity on Daphnia for the target Indole was based on Vega prediction, which provided the most reliable 96h-LC50 prediction equal to 19.76 mg/L (Pimephales promelas). The prediction was assessed as high reliable.

It should not be categorised as Aquatic toxic acut (limit 1 mg/l).

It is a readily biodegradable substance. Its log kow is 2.24. It should not be categorised as aquatic toxic chronic.

Description of key information

Acute aquatic toxicity on fish of the target chemical was estimated by using three predictors: ACD/Percepta, ECOSAR and Vega. The three predictors were employed in order to assess and combine the predictions and thus enhance the reliability of the final prediction. In the combined assessment only reliable predictions are to be taken into account.

In the case of the target Indole, the three predictors provided reliable predictions of different level of reliability (moderate ACD/Percepta, borderline ECOSAR, and high Vega). In particular, ACD/Percepta provided a moderately reliable LC50 prediction equal to 20 mg/L, ECOSAR provided a borderline reliable LC50 equal to 2.34 mg/L and Vega provided a highly reliable LC50 equal to 19.76 mg/L. The in silico assessment of acute aquatic toxicity on Daphnia for the target Indole was based on Vega prediction, which provided the most reliable 96h-LC50 prediction equal to 19.76 mg/L (Pimephales promelas). The prediction was assessed as high reliable.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

19.76 mg/L