Registration Dossier
Registration Dossier
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EC number: 259-502-5 | CAS number: 55150-29-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary source.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- ROBUST SUMMARIES for the Diethylbenzene - Rich Streams Category
- Author:
- U. S. Environmental Protection Agency (EPA)
- Year:
- 2 004
- Bibliographic source:
- ROBUST SUMMARIES for the Diethylbenzene - Rich Streams Category, U. S. Environmental Protection Agency (EPA), 201-15249B, April 26, 2004.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: TSCA guidelines
- Principles of method if other than guideline:
- Acute dermal toxicity study of Diethylbenzene (25340-17-4) in rabbits.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Diethylbenzene
- Cas Number:
- 25340-17-4
- Molecular formula:
- C30H42
- IUPAC Name:
- Diethylbenzene
- Details on test material:
- - IUPAC Name: Diethylbenzene
- Mol. formula: C10H14
- Molecular Weight: 134.2206 g/mole
- Smiles: CCc1ccccc1CC
- InChI: 1S/C10H14/c1-3-9-7-5-6-8-10(9)4-2/h5-8H,3-4H2,1-2H3
Constituent 1
- Specific details on test material used for the study:
- - IUPAC Name: Diethylbenzene
- Mol. formula: C10H14
- Molecular Weight: 134.2206 g/mole
- Smiles: CCc1ccccc1CC
- InChI: 1S/C10H14/c1-3-9-7-5-6-8-10(9)4-2/h5-8H,3-4H2,1-2H3
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: at least 8 weeks old
- Weight at study initiation: The males weighed between 2.3-2.6 kg, and the females weighed between 2.6-2.7 kg.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 60-70oF (15.5 - 21°C)
- Humidity (%):between 30-70%
Administration / exposure
- Type of coverage:
- other: Dermal
- Vehicle:
- not specified
- Details on dermal exposure:
- not specified
- Duration of exposure:
- not specified
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- Total = 10 (Male/Female)
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Other examinations performed: Animals were observed for clinical examination and body weight (loss/gain). - Statistics:
- FIFRA method was used.
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No Mortality observed
- Mortality:
- No Mortality observed at 5000 mg/kg bw
- Clinical signs:
- other: Fissuring exhibited at a small portion of the dose site, in 1 animal, no severe dermal effect were seen. Decreased food consumption was exhibited by all 10 animals on the day after dosing; by 4 animals on Day 4; and by 1 animal on Day 10.
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The LD50 was considered to be = >5000 mg/kg bw, when male and female New Zealand White rabbits were treated with Diethylbenzene (25340-17-4) by dermal application.
- Executive summary:
Acute Dermal toxicity study was conducted according to TSCA guideline in 10 Male and Female New Zealand White rabbits using Diethylbenzene at the concentration of 5000 mg/kg bw. At start of the experiment, animals were at least 8 weeks old. The males weighed between 2.3-2.6 kg, and the females weighed between 2.6-2.7 kg. Room temperature was 60-70°F, and relative humidity was between 30-70% during the study. Animals were observed for 14 days post dose.Animals were observed for clinical examination and body weight (loss/gain). FIFRA method was used.No Mortality observed at5000 mg/kg bw. Fissuring exhibited at a small portion of the dose site, in 1 animal, no severe dermal effect were seen. Decreased food consumption was exhibited by all 10 animals on the day after dosing; by 4 animals on Day 4; and by 1 animal on Day 10.All animals exhibited body weight losses or no weight change at Day 7, but most gained weight between Days 7 and 14. Therefore, LD50 was considered to be = >5000 mg/kg bw, when male and female New Zealand White rabbits were treated with Diethylbenzene (25340-17-4) by dermal application.
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