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EC number: 259-502-5 | CAS number: 55150-29-3
Genetic toxicity in vitro study was assessed for Diethyl Fumarate. For this purpose AMES test was performed according to Guidelines for Screening Mutagenicity Testing of Chemicals (Japan).The test material was exposed to Salmonella typhimurium TA100, TA1535, TA98, TA1537, E. coli WP2 uvrA in the presence and absence of metabolic activation S9. The concentration of test material used in the absence of metabolic activation were 0, 9.375, 18.75, 37.5, 75, 150, 300µg/plate (TA100),0, 78.13, 156.3, 312.5, 625, 1250, 2500µg/plate(TA1535, TA98, TA1537) and 0, 156.3 312.5, 625, 1250, 2500, 5000µg/plate (WP2). While concentration used in the presence of metabolic activation were 0, 312.5, 625, 1250, 2500 5000 µg/plate. No mutagenic effects were observed in all strains, in the presence and absence of metabolic activation. Therefore Diethyl Fumarate was considered to be non mutagenic in Salmonella typhimurium TA100, TA1535, TA98, TA1537, E. coli WP2 uvrA by AMES test. Hence the substance cannot be classified as gene mutant in vitro.
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