Registration Dossier
Registration Dossier
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EC number: 270-728-3 | CAS number: 68477-39-4 A complex combination of hydrocarbons obtained by distilling cracked stripped steam-cracked distillates. It consists of hydrocarbons having carbon numbers in the range of C8 through C10 and boiling in the range of approximately 129°C to 194°C (264°F to 382°F).
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vivo
Description of key information
Toluene has been examined for genotoxicity both in vitro and in vivo in a range of assays and has shown negative results. It is concluded that the available data are sufficient and indicate that low benzene naphtha streams have no significant genotoxicity.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Additional information from genetic toxicity in vivo:
Justification for selection of genetic toxicity endpoint
Information available for the key marker substance toluene indicate
no significant genotoxicity in vitro or in vivo.
Justification for classification or non-classification
It is concluded that the available data on the specific component toluene is sufficient for assessment and that no classification is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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