Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-072-6 | CAS number: 115-21-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1946
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study did not meet current guideline requirements in regard to various aspects of data and reporting. For example study length, number of animals and observation period deviated from the guideline, the report was lacking in details on test material and test animals. It does however, add weight of evidence for eye irritation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 951
- Report date:
- 1951
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- An effect grade system was used for assessing corneal burns of rabbit eye.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Trichloro(ethyl)silane
- EC Number:
- 204-072-6
- EC Name:
- Trichloro(ethyl)silane
- Cas Number:
- 115-21-9
- Molecular formula:
- C2H5Cl3Si
- IUPAC Name:
- trichloro(ethyl)silane
- Details on test material:
- - Name of test material (as cited in study report): Trichloroethylsilane
- Substance type: Chloro-Si
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Duration of treatment / exposure:
- No data.
- Observation period (in vivo):
- No data.
- Number of animals or in vitro replicates:
- No data.
Results and discussion
In vivo
Results
- Irritation parameter:
- cornea opacity score
- Basis:
- other: not specified
- Time point:
- other: not specified
- Remarks on result:
- other: Grade 9.
- Other effects:
- None reported.
Any other information on results incl. tables
Grade 9 corneal burns.
Applicant's summary and conclusion
- Conclusions:
- The test substance was designated Grade 9 in the rating system for corneal burns, as determined in a study which did not meet current guideline requirements as the report was lacking in details on test material and test animals. It does however, add weight of evidence for eye irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
