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Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1983

Materials and methods

Type of study / information:
Type: other: nephrotoxicity
Test guideline
Qualifier:
no guideline available
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: low viscosity liquid hydrocarbon

Results and discussion

Applicant's summary and conclusion

Conclusions:
Exposure to keosine can cause light hydrocarbon nephropathy in male rats. This male rat specific finding is reagerded as not relevant to human health
Executive summary:

The characteristic nephropathy shown by male rats when exposed to naphtha fractions used in blending gasoline has also been observed with kerosine-type jet fuels. Bruner and Pitts recorded such findings in a 90-day inhalation study with Fischer 344 rats using petroleum-derived jet fuels JP-4 and JP-5 at atmospheric concentrations of 0.15 to 1.0 mg/l. It is accepted that this effect is not relevant for humans.