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EC number: 284-965-5
CAS number: 85005-32-9
Table 5. Individual bodyweights and bodyweight changes.
Dose level, mg/kg
Animal number and sex
Bodyweight (g) at Day
Bodyweight gain (g) during week
Introduction. The study was performed to assess the acute
oral toxicity of the test material in the Wistar strain rat. The method
was designed to meet the requirements of the following:
- OECD Guideline for Testing of Chemicals No 420 “Acute oral toxicity –
fixed dose method” (adopted 17 December 2001)
- Method B1 bis Acute toxicity (oral) of Commission Regulation (EC) No.
Method. Following a sighting test at dose levels of 300
and 2000 mg/kg, a further group of four fasted female animals were given
a single oral dose of undilted test material at a dose level of 2000
mg/kg bodyweight. Clinical signs and bodyweight development were
monitored during the study. All animals were subjected to gross necropsy.
Morality. There were no deaths.
Clinical Observations. There were no signs of systemic
Bodyweight. All animals showed expected gains in
Necropsy. No abnormalities were noted at necropsy.
Conclusion. The acute oral median lethal dose (LD50) of
the test material in the female Wistar strain rat was estimated to be
greater than 2000 mg/kg bodyweight.
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