1,3-Benzenedisulfonic acid, 4-[[5-(aminocarbonyl)-1-ethyl-1,6-dihydro-2-hydroxy-4-methyl-6-oxo-3-pyridinyl]azo]-6-[[4-[[3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]-4-sulfophenyl]amino]-6-chloro-1,3,5-triazin-2-yl]amino]-

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data from secondary source

Data source

Reference

Reference 1

Reference Type:

secondary source

Title:

Acute dermal toxicity of CAS no 105-59-9

Author:

U.S .National library of medicine

Year:

2017

Bibliographic source:

ChemID plus A TOXNET DATABASE.2017

Reference 2

Reference Type:

secondary source

Title:

Acute dermal toxicity of CAS no 105-59-9

Author:

European Chemicals Bureau

Year:

2000

Bibliographic source:

IUCID Data set, European Chemicals Bureau, 18–FEB–2000, 58

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

other: As mentioned below

Principles of method if other than guideline:

Acute dermal toxicity study of Ethanol, 2.2’-(methylimino)bis- in rabbits

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2,2'-methyliminodiethanol

EC Number:

203-312-7

EC Name:

2,2'-methyliminodiethanol

Cas Number:

105-59-9

Molecular formula:

C5H13NO2

IUPAC Name:

2,2'-(methylimino)diethanol

Test material form:

other: liquid

Details on test material:

- Name of test material (as cited in study report): N-Methyldiethanolamine
- Molecular formula (if other than submission substance): C5H13NO2
- Molecular weight (if other than submission substance): 119.163 g/mol
- Substance type: Organic
- Physical state: Liquid
- SMILES: N(CCO)(CCO)C
- InChI: 1S/C5H13NO2/c1-6(2-4-7)3-5-8/h7-8H,2-5H2,1H3

Specific details on test material used for the study:

Name of test material (as cited in study report): N-Methyldiethanolamine
- Molecular formula : C5H13NO2
- Molecular weight : 119.163 g/mol
- Substance type: Organic
- Physical state: Liquid
- SMILES: N(CCO)(CCO)C
- InChI: 1S/C5H13NO2/c1-6(2-4-7)3-5-8/h7-8H,2-5H2,1H3

Test animals

Species:

rabbit

Strain:

other: New Zealand albino

Sex:

male

Details on test animals or test system and environmental conditions:

No data available

Administration / exposure

Type of coverage:

not specified

Vehicle:

not specified

Details on dermal exposure:

No data available

Doses:

5990 mg/kg bw

No. of animals per sex per dose:

4

Control animals:

not specified

Details on study design:

No data available

Statistics:

No data available

Results and discussion

Preliminary study:

No data available

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

> 5 990 mg/kg bw

Based on:

test mat.

Remarks on result:

other: No mortality observed in treated rabbits

Mortality:

No mortality observed in treated rabbits

Clinical signs:

No data available

Body weight:

No data available

Gross pathology:

No data available

Other findings:

No data available

Applicant's summary and conclusion

Interpretation of results:

other: Not classified

Conclusions:

LD50 was considered to be > 5990 mg/kg bw when 4 male New Zealand albino rabbits were treated with Ethanol, 2.2’-(methylimino)bis- (MDEA) dermally

Executive summary:

In dermal toxicity study,4 male New Zealand albino rabbits were treated with Ethanol, 2.2’-(methylimino)bis- (MDEA) in the concentration of 5990 mg/kg bw dermally. No mortality observed in treated rabbits. Therefore, LD50 was considered to be > 5990 mg/kg bw when 4 male New Zealand albino rabbits were treated with Ethanol, 2.2’-(methylimino)bis- (MDEA) (105 -59 -9) by dermal application .