Registration Dossier
Registration Dossier
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EC number: 300-530-5 | CAS number: 93941-80-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data from secondary source
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Acute dermal toxicity of CAS no 105-59-9
- Author:
- U.S .National library of medicine
- Year:
- 2 017
- Bibliographic source:
- ChemID plus A TOXNET DATABASE.2017
- Reference Type:
- secondary source
- Title:
- Acute dermal toxicity of CAS no 105-59-9
- Author:
- European Chemicals Bureau
- Year:
- 2 000
- Bibliographic source:
- IUCID Data set, European Chemicals Bureau, 18–FEB–2000, 58
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute dermal toxicity study of Ethanol, 2.2’-(methylimino)bis- in rabbits
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- yes
Test material
- Reference substance name:
- 2,2'-methyliminodiethanol
- EC Number:
- 203-312-7
- EC Name:
- 2,2'-methyliminodiethanol
- Cas Number:
- 105-59-9
- Molecular formula:
- C5H13NO2
- IUPAC Name:
- 2,2'-(methylimino)diethanol
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): N-Methyldiethanolamine
- Molecular formula (if other than submission substance): C5H13NO2
- Molecular weight (if other than submission substance): 119.163 g/mol
- Substance type: Organic
- Physical state: Liquid
- SMILES: N(CCO)(CCO)C
- InChI: 1S/C5H13NO2/c1-6(2-4-7)3-5-8/h7-8H,2-5H2,1H3
Constituent 1
- Specific details on test material used for the study:
- Name of test material (as cited in study report): N-Methyldiethanolamine
- Molecular formula : C5H13NO2
- Molecular weight : 119.163 g/mol
- Substance type: Organic
- Physical state: Liquid
- SMILES: N(CCO)(CCO)C
- InChI: 1S/C5H13NO2/c1-6(2-4-7)3-5-8/h7-8H,2-5H2,1H3
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand albino
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- No data available
- Doses:
- 5990 mg/kg bw
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 990 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality observed in treated rabbits
- Mortality:
- No mortality observed in treated rabbits
- Clinical signs:
- No data available
- Body weight:
- No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- LD50 was considered to be > 5990 mg/kg bw when 4 male New Zealand albino rabbits were treated with Ethanol, 2.2’-(methylimino)bis- (MDEA) dermally
- Executive summary:
In dermal toxicity study,4 male New Zealand albino rabbits were treated with Ethanol, 2.2’-(methylimino)bis- (MDEA) in the concentration of 5990 mg/kg bw dermally. No mortality observed in treated rabbits. Therefore, LD50 was considered to be > 5990 mg/kg bw when 4 male New Zealand albino rabbits were treated with Ethanol, 2.2’-(methylimino)bis- (MDEA) (105 -59 -9) by dermal application .
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