reaction product of aminoacids and palmitoyl chloride

Partition coefficient

Administrative data

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

22/03/2010-21/05/2010

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2011

Report date:

2011

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.8 (Partition Coefficient - Shake Flask Method)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

other: Shake Flask Method

Partition coefficient type:

octanol-water

Test material

Test material information

Constituent 1

Test material form:

solid

Details on test material:

Test ITEM : LCE08115 (SEPIFEEL ONE)
Batch N° : 826900020
The test item consist in a mix of palmitoyl proline, magnesium palmitoyl glutamate and sodium palmitoyl sarcosinate (CAS N°59441-32-6, CAS N°57539-47-6, CAS N°4028-10-8).

The specimen was shipped at room temperature on behalf of Mr Olivier DENNY from DEFITRACES
It was treated according to the ANADIAG procedure PG 0204 for receipt, identification and storage.
The characteristics of the transport, of the receipt and of the storage in ANADIAG facilities were all registered and are summarised in the following table.
Table of shipment and storage:
Sample n°: LCE08115 Batch N° 826900020
Anadiag n°: 1480/A
Temperature during the transportation: Room temperature
Transportation date: 11.09.09
Date of receipt at the test facility: 14.09.09
Amount received: 90g
Condition of specimen upon receipt: Ok
Storage temperature: Room temperature

The maximum temperature was daily recorded and was below 30 °C during the storage period
The test item was stored away from moisture and direct light.
The sample was submitted to the test as received.

Specific details on test material used for the study:

Test ITEM : LCE08115 (SEPIFEEL ONE)
Batch N° : 826900020
The test item consist in a mix of palmitoyl proline, magnesium palmitoyl glutamate and sodium palmitoyl sarcosinate (CAS N°59441-32-6, CAS N°57539-47-6, CAS N°4028-10-8).

The specimen was shipped at room temperature on behalf of Mr Olivier DENNY from DEFITRACES
It was treated according to the ANADIAG procedure PG 0204 for receipt, identification and storage.
The characteristics of the transport, of the receipt and of the storage in ANADIAG facilities were all registered and are summarised in the following table.
Table of shipment and storage:
Sample n°: LCE08115 Batch N° 826900020
Anadiag n°: 1480/A
Temperature during the transportation: Room temperature
Transportation date: 11.09.09
Date of receipt at the test facility: 14.09.09
Amount received: 90g
Condition of specimen upon receipt: Ok
Storage temperature: Room temperature

The maximum temperature was daily recorded and was below 30 °C during the storage period
The test item was stored away from moisture and direct light.
The sample was submitted to the test as received.

Study design

Analytical method:

high-performance liquid chromatography

Results and discussion

Partition coefficient

Key result

Type:

log Pow

Partition coefficient:

>= 2.42 - <= 2.84

Temp.:

20.2 °C

pH:

ca. 6.2

Applicant's summary and conclusion

Conclusions:

The value of partition coefficient found for the test item LCE08115 is :
Pow= 4.61E+02 and Log(Pow) = 2.63. at 20.2°C in purified water(pH 6.2).

Executive summary:

The n-octanol/water partition coefficient of the test item LCE08115 at 20.2°C and at pH 6.2 is

Pow = 4.61E+02 and Log (Pow) = 2.63